目的 研究复方苦参注射液联合注射用羟喜树碱治疗膀胱癌的临床疗效。方法 选取2015年4月-2017年4月天津市东丽区东丽医院收治的60例膀胱癌患者，将所有患者随机分为两组，每组各30例。对照组膀胱灌注注射用羟喜树碱，将20 mg注射用羟喜树碱溶于50 mL生理盐水中，用注射器将羟喜树碱直接推注到膀胱内，然后用10 mL生理盐水将尿道内的羟基喜树碱液冲入膀胱，使羟基喜树碱液在膀胱内保留2 h，患者俯卧、仰卧和左、右侧卧各保持15 min，每周1次。治疗组在对照组治疗的基础上静脉滴注复方苦参注射液，10 mL溶于0.9%氯化钠注射液250 mL中，1次/d。两组均治疗2个月。观察两组患者的临床疗效，同时比较两组的生活质量评分、生存率和复发率。结果 治疗后，对照组临床总有效率（RR）为43.33%，临床收益率（DCR）为60.00%；治疗组RR为56.67%，DCR为73.33%，两组RR、DCR比较差异有统计学意义（P<0.05）。治疗后，两组患者躯体和心理相关生活质量评分均显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组患者生活质量评分显著高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组的生存率分别为50.00%、63.33%，两组生存率比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组复发率分别为23.33%、10.00%，两组复发率比较差异具有统计学意义（P<0.05）。结论 复方苦参注射液联合注射用羟喜树碱治疗膀胱癌具有较好的临床疗效，可显著改善生活质量，提高生存率，减小复发率，安全性较高，具有一定的临床应用价值。

Objective To investigate the clinical effect of Compound Kushen Injection combined with Hydroxycamptothecin for injection in treatment of bladder cancer. Methods Patients (60 cases) with bladder cancer in Dongli Hospital of Dongli District in Tianjin from April 2015 to April 2017 were randomly divided into control group and treatment group, each group had 30 cases. Patients in the control group were administered with Hydroxycamptothecin for injection by irrigation of bladder, 20 mg was added to 50 mL normal saline, and injected into the bladder with a syringe, then the hydroxycamptothecin solution in the urethra was flushed into the bladder with 10 mL normal saline, so that the hydroxycamptothecin solution was retained in the bladder for 2 h, and the patient remained prone, supine, left and right lying for 15 min, once a week. Patients in the treatment group were iv administered with Compound Kushen Injection on the basis of the control group, 10 mL added into 0.9% NaCl injection 250 mL, once daily. Patients in two groups were treated for 2 month. After treatment, the clinical efficacies were evaluated, and quality of life score, survival and recurrence rates in two groups were compared. Results After treatment, the RR and DCR in the control group were 43.33% and 60.00%, and the RR and DCR in the treatment group were 56.67% and 73.33%, and there were differences between two groups (P<0.05). After treatment, the physical and psychological quality of life scores in two groups were significantly increased, and there were differences in the same group (P<0.05). After treatment, the quality of life score in the treatment group was significantly higher than that in the control group, and there were differences between two groups (P<0.05). After treatment, the survival rates in the control and treatment groups were 50.00% and 63.33%, respectively, and there was difference between two groups (P<0.05). After treatment, the recurrence rates in the control and treatment groups were 23.33% and 10.00%, respectively, and there was difference between two groups (P<0.05). Conclusion Compound Kushen Injection combined with Hydroxycamptothecin for injection has significant clinical effect in treatment of bladder cancer, can significantly improve the quality of life, increase the survival rate, and reduce the recurrence rate, with high safety, which has a certain clinical application value.