目的 探讨荆花胃康胶丸联合艾普拉唑肠溶片治疗十二指肠溃疡的临床疗效。方法 选取2015年8月-2017年8月在西安市第九医院治疗的十二指肠溃疡患者120例，根据用药不同分为对照组（60例）和治疗组（60例）。对照组晨起口服艾普拉唑肠溶片，10 mg/次，1次/d；治疗组在对照组基础上口服荆花胃康胶丸，160 mg/次，3次/d。两组均经过4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分、促溃疡愈合因子和胃肠激素水平。结果 治疗后，对照组和治疗组临床有效率分别为81.67%和96.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者溃疡痛评分、腹胀评分、反酸嗳气评分均显著降低（P<0.05），且治疗组降低比对照组更明显（P<0.05）。治疗后，两组患者基质金属蛋白酶-9（MMP-9）水平显著降低（P<0.05），血管内皮生长因子（VEGF）和前列腺素E2（PGE₂）水平显著升高（P<0.05），且治疗组MMP-9、VEGF和PGE₂水平明显好于对照组（P<0.05）。治疗后，两组患者肾上腺髓质素（AM）和胃肠激素胃泌素（GAS）水平均显著降低（P<0.05），生长抑素（SS）和降钙素基因相关肽水平（CGRP）水平均显著升高（P<0.05），且治疗组AM、GAS、CGRP和SS水平明显好于对照组（P<0.05）。结论 荆花胃康胶丸联合艾普拉唑肠溶片治疗十二指肠溃疡可有效改善患者临床症状和胃肠激素水平，促进溃疡愈合，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Jinghua Weikang Capsules combined with ilaprazole in treatment of duodenal ulcer. Methods Patients (120 cases) with duodenal ulcer in the Ninth Hospital of Xi'an from August 2015 to August 2017 were divided into control (60 cases) and treatment (60 cases) groups according to different treatments. Patients in the control group were po administered with Ilaprazole Enteric-coated Tablets in the morning, 10 mg/time, once daily. Patients in the treatment group were po administered with Jinghua Weikang Capsules on the basis of the control group, 160 mg/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, the ulcer healing factors and the gastrointestinal hormone levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 81.67% and 96.67% respectively, and there were differences between two groups (P<0.05). After treatment, the ulcer pain, abdominal distention, acid regurgitation and belching scores in two groups were significantly decreased (P<0.05), and these clinical symptom scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the MMP-9 levels in two groups were significantly decreased (P<0.05), VEGF and PGE₂ levels were significantly increased (P<0.05), and the MMP-9, VEGF and PGE₂ levels in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the AM and GAS levels in two groups were significantly decreased (P<0.05), CGRP and SS levels were significantly increased (P<0.05), and these gastrointestinal hormone levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Jinghua Weikang Capsules combined with ilaprazole in treatment of duodenal ulcer can effectively improve the clinical symptoms and the gastrointestinal hormone levels, and promote the healing of the ulcer, which has a certain clinical application value.