目的 探讨胃得安胶囊联合铝碳酸镁治疗老年慢性胃炎的临床有效性与安全性。方法 选取2015年7月-2017年7月在青海大学附属医院消化内科确诊并治疗的老年慢性胃炎患者152例作为研究对象，随机分为对照组和治疗组，每组各76例。对照组口服铝碳酸镁咀嚼片，1片/次，3次/d。治疗组在对照组治疗基础上口服胃得安胶囊，5片/次，3次/d。两组患者均连续治疗6周。观察两组的临床疗效，比较两组临床症状消失时间、胃蛋白酶原、胃肠道症状分级评分（GSRS）量表评分、症状积分。结果 治疗后，对照组和治疗组患者的总有效率分别为80.85%、95.74%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患者上腹疼痛消失时间、烧灼反酸消失时间、嗳气消失时间等临床症状消失时间均显著短于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者的胃蛋白酶原I、胃蛋白酶原Ⅱ、GSRS评分及症状积分均较治疗前显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组胃蛋白酶原I、胃蛋白酶原Ⅱ、GSRS评分及症状积分显著低于对照组，两组比较差异有统计学意义（P<0.05）。结论 胃得安胶囊联合铝碳酸镁治疗老年慢性胃炎疗效显著，可显著改善患者临床症状，同时安全性高，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy and safety of Weidean Capsules combined with hydrotalcite in treatment of senile chronic gastritis. Methods Patients (152 cases) with senile chronic gastritis in Department of Gastroenterology from Affiliated Hospital of Qinghai University from July 2015 to July 2017 were divided into control (76 cases) and treatment (76 cases) groups. Patients in the control group were po administered with Hydrotalcite Chewable Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Weidean Capsules on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom disappearance time, pepsinogen, GSRS and symptom scores were compared between the two groups. Results After treatment, the clinical efficacy in the control and treatment group were 80.85% and 95.74%, and there were differences between two groups (P<0.05). The upper abdominal pain disappearance time, burning antacids disappearance time, and belching disappearance time in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, the pepsin I, pepsin Ⅱ, GSRS and symptom scores in the two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the pepsin I, pepsin Ⅱ, GSRS and symptom scores in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Weidean Capsules combined with hydrotalcite has significant clinical effect in treatment of senile chronic gastritis, and can significantly improve the clinical symptoms of patients with high safety, which has a certain clinical application value.