目的 探讨羔羊胃提取物维B12胶囊联合瑞巴派特片治疗慢性萎缩性胃炎的临床疗效。方法 选取2017年3月-2018年3月在四川绵阳四0四医院治疗的慢性萎缩性胃炎患者86例，根据用药差别分成对照组（43例）和治疗组（43例）。对照组口服瑞巴派特片，0.1 g/次，3次/d；治疗组在对照组基础上口服羔羊胃提取物维B12胶囊，3粒/次，3次/d。两组均经过4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分、胃泌素-17（G-17）、胃蛋白酶原Ⅰ（PGI）、表皮生长因子（EGF）和降钙素基因相关肽（CGRP）水平。结果 治疗后，对照组临床有效率为81.40%，显著低于治疗组的97.67%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者胃痛、呃逆、倦怠乏力、痞满等临床症状评分均显著降低（P<0.05），且治疗组各项临床症状评分明显低于对照组（P<0.05）。治疗后，两组患者血清PGI、G-17和CGRP水平均显著升高（P<0.05），EGF水平显著降低（P<0.05），且治疗组PGI、G-17、CGRP和EGF水平明显好于对照组（P<0.05）。结论 羔羊胃提取物维B12胶囊联合瑞巴派特片治疗慢性萎缩性胃炎可有效改善患者临床症状和胃功能相关指标，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Lamb's Tripe Extract and Vitamin B12 Capsule combined with rebamipide in treatment of chronic atrophic gastritis. Methods Patients (86 cases) with chronic atrophic gastritis in Sichuan Mianyang 404 Hospital from March 2017 to March 2018 were divided into control (43 cases) and treatment (43 cases) groups according to different treatments. Patients in the control group were po administered with Rebamipide Tablets, 0.1 g/time, three times daily. Patients in the treatment group were po administered with Lamb's Tripe Extract and Vitamin B12 Capsule on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, G-17, PGI, EGF and CGRP levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the stomachache, hiccup, tiredness and weakness, distention and fullness scores in two groups were significantly decreased (P<0.05), and these clinical symptom scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the PGI, G-17 and CGRP levels in two groups were significantly increased (P<0.05), EGF levels in two groups were significantly decreased (P<0.05), and the PGI, G-17, CGRP and EGF levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Lamb's Tripe Extract and Vitamin B12 Capsule combined with rebamipide in treatment of chronic atrophic gastritis can effectively improve the clinical symptoms and the stomach function related indexes, which has a certain clinical application value.