目的 探讨疏风解毒胶囊联合盐酸左氧氟沙星片治疗慢性支气管炎急性加重期的临床疗效。方法 选取2014年10月-2016年12月辽河油田总医院诊治的120例慢性支气管炎急性加重期患者为研究对象，根据治疗方法将所有患者随机分为对照组和治疗组，每组各60例。对照组口服盐酸左氧氟沙星片，1片/次，1次/d；治疗组在对照组治疗的基础上口服疏风解毒胶囊，4粒/次，3次/d。两组患者均连续治疗7 d。观察两组患者临床疗效，同时比较两组症状体征消退时间、血清炎性细胞因子水平和不良反应情况。结果 治疗后，对照组和治疗组的总有效率分别为83.3%、95.0%，两组比较差异具有统计学意义（P<0.05）。治疗组患者咳嗽、咳痰、肺部啰音、发热消退时间明显短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者C反应蛋白（CRP）、肿瘤坏死因子α（TNF-α）、白细胞介素-8（IL-8）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血清炎性细胞因子水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗期间，对照组不良反应发生率为20.0%，明显高于治疗组的6.7%，两组比较差异具有统计学意义（P<0.05）。结论 疏风解毒胶囊联合盐酸左氧氟沙星片治疗慢性支气管炎急性发作具有较好的临床疗效，可快速缓解临床症状，降低炎症因子水平，安全性高，具有一定的临床推广价值。

Objective To investigate the clinical efficacy of Shufeng Jiedu Capsules combined with Levofloxacin Hydrochloride Tablets in treatment of acute exacerbation of chronic bronchitis. Methods Patients (120 cases) with acute exacerbation of chronic bronchitis in Liaohe Oilfield General Hospital from October 2014 to December 2016 were randomly divided into control and treatment group according to the treatment method, and each group had 60 cases. Patients in the control group were po administered with Levofloxacin Hydrochloride Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Shufeng Jiedu Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the disappearance time of symptoms and signs, the levels of serum inflammatory cytokines, and adverse reactions in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.3% and 95.0%, respectively, and there were differences between two groups (P<0.05). The disappearance times of cough, expectoration, lung rales and fever in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, the levels of CRP, TNF-α, and IL-8 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the levels of serum inflammatory cytokines in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). During the treatment, the adverse reaction rate in the control group was 20.0%, which was significantly higher than 6.7% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Shufeng Jiedu Capsules combined with Levofloxacin Hydrochloride Tablets has significant clinical effect in treatment of acute exacerbation of chronic bronchitis, can quickly relieve clinical symptoms, reduce the levels of inflammatory cytokines, with high safety, which has a certain clinical application value.