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[摘要]
目的 探讨芪血通络片联合硫酸氢氯吡格雷片治疗脑梗死的临床疗效。方法 选取2017年5月-2018年5月在新疆医科大第一附属医院十二师分院进行治疗的脑梗死患者118例为研究对象,将所有患者随机分为对照组和治疗组,每组各59例。对照组口服硫酸氢氯吡格雷片,2片/次,1次/d;治疗组在对照组治疗的基础上口服芪血通络片,4片/次,3次/d。所有患者均治疗90 d。观察两组患者的临床疗效,同时比较治疗前后两组的美国国立卫生研究院卒中量表(NIHSS)评分、Fugl-Meyer运动功能评分法(FMA)评分、BI指数评分、卒中专门生存质量量表(SS-QOL)评分、血脂和血液流变学指标。结果 治疗后,对照组和治疗组的总有效率分别为78.1%、91.5%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分明显降低,FMA评分、BI指数和SS-QOL评分明显增加,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组上述评分显著优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血脂TC水平、血浆比黏度、高切黏度、红细胞压积均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组患者血脂和血液流变指标显著低于对照组,两组比较差异具有统计学差异(P<0.05)。结论 芪血通络片联合硫酸氢氯吡格雷片治疗脑梗死具有较好的临床疗效,可显著提高患者的神经功能、生活能力和生活质量,改善血脂和血液流变指标,安全性好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Qixue Tongluo Tablets combined with Clopidogrel Bisulfate Tablets in the treatment of cerebral infarction. Methods Patients (118 cases) with cerebral infarction in the Twelfth Division of the First Affiliated Hospital of Xinjiang Medical University from May 2017 to May 2018 were randomly divided into control and treatment groups, and each group had 59 cases. Patients in the control group were po administered with Clopidogrel Bisulfate Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Qixue Tongluo Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 90 d. After treatment, the clinical efficacy was evaluated, and the NIHSS score, FMA score, BI index, SS-QOL score, blood lipid, and hemorheology indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 78.1% and 91.5%, and there were differences between two groups (P<0.05). After treatment, NIHSS score in two groups were significantly decreased, but FMA scores, BI indexes, and SS-QOL scores were significantly increased, and there were differences in the same group (P<0.05). After treatment, the scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, serum lipid TC level, plasma specific viscosity, high shear viscosity, and hematocrit in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, blood lipid and hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Qixue Tongluo Tablets combined with Clopidogrel Bisulfate Tablets has clinical curative effect in treatment of cerebral infarction, can significantly improve patients' neurological function, living capacity and quality of life, and improve blood lipids and blood rheology indexes, with good safety, which has a certain clinical application value.
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