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[摘要]
目的 探讨多廿烷醇片联合阿托伐他汀钙片治疗老年高脂血症的临床疗效。方法 选取2015年2月-2016年5月开滦总医院收治的高脂血症患者180例,根据所用调脂方案分为多廿烷醇组、阿托伐他汀组和联合治疗组,每组各60例,每组各60例。多廿烷醇组晚上口服多廿烷醇片,20 mg/次,1次/d。阿托伐他汀组晚上口服阿托伐他汀钙片,20 mg/次,1次/d。联合治疗组给予多廿烷醇片和阿托伐他汀钙片,方法同上。所有患者均连续治疗24周。观察两组的临床疗效,比较两组的血脂水平、血小板计数(PLT)和颈动脉内膜中层厚度(IMT)。结果 治疗后,多廿烷醇组、阿托伐他汀组和联合治疗组总有效率分别为80.00%、78.33%、93.33%,联合治疗组与多廿烷醇组和阿托伐他汀组比较差异有统计学意义(P<0.05)。治疗后,3组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均显著下降,同组治疗前后比较差异有统计学意义(P<0.05);且联合治疗组血脂水平明显低于多廿烷醇组、阿托伐他汀组,3组比较差异有统计学意义(P<0.05)。治疗后,3组PLT和IMT没有显著变化,3组比较差异无统计学意义。结论 多廿烷醇片联合阿托伐他汀钙片治疗老年高脂血症具有较好的临床疗效,可有效调节血脂水平,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effects of Policosanol Tablets combined with Atorvastatin Calcium Tablets in treatment of hyperlipidemia in the elderly. Methods Elderly patients (180 cases) with hyperlipidemia in Kailuan General Hospital from February 2015 to May 2016 were randomly divided into policosanol, atorvastatin, and combined treatment groups, and each group had 60 cases. Elderly patients in the policosanol group were po administered with Policosanol Tablets, 20 mg/time, once daily. Elderly patients in the atorvastatin group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Elderly patients in the combined treatment group were given Pregabalin Capsules and Paracetamol and Tramadol Hydrochloride Tablets, usage as before. Patients in three groups were treated for 24 weeks. After treatment, the clinical efficacies were evaluated, and blood lipid levels, PLT, and IMT in two groups were compared. Results After treatment, the clinical efficacies in the policosanol, atorvastatin, and combined treatment groups were 80.00%, 78.33%, and 93.33%, respectively, and there was difference between combined treatment group with policosanol group and atorvastatin group (P<0.05). After treatment, the levels of TC, TG, and LDL-C in three groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And blood lipid levels in the combined treatment group were significantly lower than those in the policosanol group and the atorvastatin group, with significant difference among three groups (P<0.05). After treatment, the PLT and IMT in three groups had no significantly change, and there was no difference among three groups. Conclusion Policosanol Tablets combined with Atorvastatin Calcium Tablets has clinical curative effect in treatment of hyperlipidemia in the elderly, can effectively regulate blood lipid levels, with good safety, which has a certain clinical application value.
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