[关键词]
[摘要]
大黄素是一种蒽醌衍生物,具有抑菌、抗炎、抗纤维化、保护胃肠道黏膜屏障等功效。大黄素能通过多种作用机制对胃肠道黏膜产生保护作用,具体体现在其可减少缺血后再灌注损伤、抑制炎症的产生、清除或抑制氧自由基、调节胃肠道内分泌、促进损伤后修护、保护细胞间紧密连接等,研发以大黄素为主要成分的新型胃肠道黏膜保护剂,可为胃肠道黏膜损伤性疾病的治疗提供新的治疗手段。
[Key word]
[Abstract]
Emodin is an anthraquinone derivative with antibacterial, anti-inflammatory, antifibrotic, and protective gastrointestinal mucosa barriers. Emodin can protect gastrointestinal mucosa through various mechanisms, including reducing ischemia-reperfusion injury, inhibiting the production of inflammation, removing or inhibiting oxygen free radicals, regulating gastrointestinal endocrine secretion, promoting post-injury repair, and protecting intercellular tightness, etc. The development of new gastrointestinal mucosa protective agent with emodin as the main ingredient can provide a new treatment method for the treatment of gastrointestinal mucosal injury.
[中图分类号]
[基金项目]