[关键词]
[摘要]
莪术醇是莪术挥发油中的重要活性成分,属于倍半萜类化合物,具有抗肿瘤、抗病毒、抗炎、抗早孕等广泛的生物活性,尤其以抗肿瘤作用表现突出,临床应用广泛。但由于其独特的五元并七元环化学结构,药物溶解性较差,生物利用度不高,为了改善其物理性质,提高作用强度,通过化学合成和微生物合成途径,广泛的对其开展结构修饰与衍生物合成研究。对莪术醇的结构修饰研究情况进行综述,以期为新的抗肿瘤药物的研发提供参考。
[Key word]
[Abstract]
Curcumol is an important active ingredients in the volatile oil of Curcumae Rhizoma. Curcumol is a compound of sesquitterpenes, which has a wide range of biological activities such as anti-tumor, anti-virus, anti-inflammation, and anti-early pregnancy. Especially in antitumor action, it has been widely applicated in clinic. However, due to its unique five-element and seven-element ring chemical structure, drug solubility is poor and bioavailability is not high. In order to improve the physical properties and enhance the strength of action, the structural modification and derivative synthesis have been extensively studied through chemical synthesis and microbial synthesis. The structure modification research of curcumol is summarized, in order to provide reference for research and development of new antitumor drugs
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