目的 探讨通滞苏润江胶囊联合依托考昔治疗骨关节炎的临床疗效。方法 选取2017年1月-2018年1月海南医学院第一附属医院收治的骨关节炎患者60例，随机分成对照组和治疗组，每组各30例。对照组患者口服依托考昔片，1片/次，1次/d；治疗组患者在对照组基础上口服通滞苏润江胶囊，5粒/次，2次/d。两组患者均治疗6周。观察两组患者临床疗效，同时比较治疗前后两组患者WOMAC评分、视觉模拟评分（VAS）及基质金属蛋白酶-3（MMP-3）、NO和金属蛋白酶组织抑制因子-1（TIMP-1）水平。结果 治疗后，对照组和治疗组的总有效率分别为76.67%、96.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者WOMAC和VAS评分均显著降低（P<0.05），且治疗组患者WOMAC和VAS评分明显低于对照组（P<0.05）。治疗后，两组患者MMP-3和NO水平显著降低（P<0.05），TIMP-1水平显著升高（P<0.05），且治疗组患者MMP-3、NO和TIMP-1的治疗后水平明显优于对照组患者（P<0.05）。结论 通滞苏润江胶囊联合依托考昔治疗骨关节炎疗效显著，可明显改善患者关节酸痛等临床症状，降低炎症反应性，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Tongzhi Surunjiang Capsules combined with etoricoxib in treatment of osteoarthritis. Methods Patients (60 cases) with osteoarthritis in the First Affiliated Hospital of Hainan Medical University from January 2017 to January 2018 were randomly divided into control and treatment groups, and each group had 30 cases. Patients in the control group were po administered with Etoricoxib Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Tongzhi Surunjiang Capsules on the basis of the control group, 5 tablets/time, twice daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and the WOMAC scores, VAS, MMP-3, NO and TIMP-1 levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 76.67% and 96.67% respectively, and there were differences between two groups (P < 0.05). After treatment, the WOMAC scores and VAS in two groups were significantly decreased (P < 0.05), and these scores in the treatment group after treatment were significantly lower than those in the control group (P < 0.05). After treatment, the MMP-3 and NO levels in two groups were significantly decreased (P < 0.05), TIMP-1 levels were significantly increased (P < 0.05), and the MMP-3, NO and TIMP-1 levels in the treatment group after treatment were significantly better than those in the control group (P < 0.05). Conclusion Tongzhi Surunjiang Capsules combined with etoricoxib has significant curative effect on osteoarthritis, which can significantly improve the clinical symptoms of joint pain and reduce the inflammatory response, which has a certain clinical application value.