[关键词]
[摘要]
目的 探讨注射用白眉蛇毒血凝酶联合雷贝拉唑钠肠溶片治疗上消化道出血的临床疗效和不良反应。方法 选取2015年3月-2017年10月海安市人民医院收治的上消化道出血患者168例为研究对象,所有患者随机分为对照组和治疗组,每组各84例。对照组口服雷贝拉唑钠肠溶片,20 mg/次,1次/d。治疗组在对照组治疗的基础上静脉滴注注射用白眉蛇毒血凝酶,2 kU加入到0.9%氯化钠溶液100 mL中,1次/d。两组患者均连续治疗5 d。观察两组的临床疗效,比较两组的止血时间、再出血率、输血量和不良反应。结果 治疗后,对照组和治疗组患者的总有效率分别为79.8%、92.9%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组止血时间、再出血率和输血量均低于对照组,两组比较差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义。结论 注射用白眉蛇毒血凝酶联合雷贝拉唑钠肠溶片治疗上消化道出血具有较好的临床疗效,可缩短患者止血时间,降低输血量,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical effect and adverse reactions of Hemocoagulase for injection combined with Sodium Rabeprazole Enteric-coated Tablets in treatment of upper gastrointestinal bleeding. Methods Patients (168 cases) with upper gastrointestinal bleeding in Haian People's Hospital from March 2015 to October 2017 were randomly divided into control and treatment groups, and each group had 84 cases. Patients in the control group were po administered with Sodium Rabeprazole Enteric-coated Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Hemocoagulase For injection on the basis of the control group, 2 kU added into normal saline 100 mL, once daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and hemostasis time, hemorrhage, blood transfusion volume, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.8% and 92.9%, respectively, and there was difference between two groups (P < 0.05). After treatment, hemostasis time, hemorrhage, and blood transfusion volume in the treatment group were significantly lower than those in the control group, and there was difference between two groups (P < 0.05). There were no differences of adverse reactions between two groups.Conclusion Hemocoagulase for injection combined with Sodium Rabeprazole Enteric-coated Tablets has clinical curative effect in treatment of upper gastrointestinal bleeding, can shorten the time of hemostasis, and reduce the amount of blood transfusion, which has a certain clinical application value.
[中图分类号]
[基金项目]