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[摘要]
目的 探讨布拉氏酵母菌散联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎的临床疗效。方法 选取2015年1月-2017年8月恩施土家族苗族自治州中心医院收治的溃疡性结肠炎患者110例为研究对象,根据随机区组设计法将患者分为对照组和治疗组,每组各55例。对照组口服柳氮磺吡啶肠溶片,1 g/次,4次/d。治疗组在对照组治疗的基础上口服布拉氏酵母菌散,0.25 g/次,2次/d。两组患者均连续治疗4周。观察两组的临床疗效,比较两组的临床症状消失时间、Sutherland疾病活动指数(DAI)评分、内镜分级评分、血清炎性因子水平。结果 治疗后,对照组和治疗组的总有效率分别为78.2%、94.5%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组腹泻、腹痛、脓血便、发热消失时间显著短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组Sutherland ADI评分和内镜分级评分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、干扰素-γ(IFN-γ)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组血清炎性因子水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 布拉氏酵母菌散联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎具有较好的临床疗效,可改善临床症状,降低炎性因子水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the effect of Saccharomyces Boulardii Sachets combined with Sulfasalazine Enteric-coated Tablets in treatment of ulcerative colitis. Methods Patients (110 cases) with ulcerative colitis in the Central Hospital of Enshi Autonomous Prefecture from January 2015 to August 2017 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 1 g/time, four times daily. Patients in the treatment group were po administered with Saccharomyces Boulardii Sachets on the basis of the control group, 0.25 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance times of clinical symptoms, Sutherland ADI score, endoscopic grading score, and levels of serum inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.2% and 94.5%, respectively, and there was difference between two groups (P < 0.05). After treatment, the disappearance times of diarrhoea, abdominal pain, bloody purulent stool, and fever in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, Sutherland ADI score and endoscopic grading score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of IL-6, IL-8, and IFN-γ in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the levels of serum inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Saccharomyces Boulardii Sachets combined with Sulfasalazine Enteric-coated Tablets has clinical curative effect in treatment of ulcerative colitis, can improve clinical symptoms, and decrease the inflammatory factor levels, which has a certain clinical application value.
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