目的 探讨硫酸氨基葡萄糖胶囊联合利多卡因治疗颞下颌关节紊乱综合征的临床疗效。方法 选取2016年3月-2017年3月在西宁市第一人民医院治疗的颞下颌关节紊乱综合征患者86例，根据用药差别分为对照组（43例）和治疗组（43例）。对照组患者推针刺入下关节囊2 mL盐酸利多卡因注射液、500 μg维生素B₁₂和5 mg地塞米松磷酸钠注射液配制成的混合溶液1 mL，2次/d；治疗组在对照组基础上口服硫酸氨基葡萄糖胶囊，2粒/次，3次/d。两组患者均经过4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者VAS、Helkimo和OHIP-14评分及关节液中炎性因子水平。结果 治疗后，对照组临床有效率为81.40%，显著低于治疗组的97.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组VAS评分、Helkimo临床功能障碍指数评分和OHIP-14量表评分均显著降低（P<0.05），且治疗后治疗组VAS、Helkimo和OHIP-14评分明显低于对照组（P<0.05）。治疗后，两组关节液中白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNF-α）水平显著降低，胰岛素样生长因子-1（IGF-1）和转化生长因子β1（TGF-β1）显著升高，同组比较差异具有统计学意义（P<0.05）；且治疗后治疗组关节液中炎性细胞水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 硫酸氨基葡萄糖胶囊联合利多卡因治疗颞下颌关节紊乱综合征可有效改善患者临床症状，提高患者生活质量，降低炎性反应，促进软骨细胞修复。

Objective To investigate the clinical efficacy of Glucosamine Sulfate Capsules combined with lidocaine in treatment of temporomandibular joint disturbance syndrome. Methods Patients (86 cases) with temporomandibular joint disturbance syndrome in Xining First People's Hospital from March 2016 to March 2017 were divided into control (43 cases) and treatment (43 cases) groups based on different treatment. Patients in the control group were pushed acupuncture into lower joint capsule administered with 1 mL mixed solution of 2 mL Lidocaine Hydrochloride Injection, 500 μg Vitamin B₁₂ and 5 mg dexamethasone Sodium Phosphate Injection, twice daily. Patients in the treatment group were po administered with Glucosamine Sulfate Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the VAS, Helkimo, and OHIP-14 scores, and the levels of inflammatory factors in joint fluid in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the VAS, Helkimo, and OHIP-14 scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group after treatment were significantly lower than those in the control group (P < 0.05). After treatment, the IL-1 and TNF-α levels in two groups were significantly decreased, but IGF-1 and TGF-β1 levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the levels of inflammatory factors in joint fluid in the treatment group after treatment were significantly better than those in the control group (P < 0.05). Conclusion Glucosamine Sulfate Capsules combined with lidocaine in treatment of temporomandibular joint disturbance syndrome can effectively improve the clinical symptoms, improve the quality of life, reduce the inflammatory response and promote the repair of cartilage cells.