目的 探讨大黄蛰虫胶囊联合注射用醋酸曲普瑞林治疗子宫内膜异位症的临床疗效。方法 选取2017年1月-2018年2月山东中医药大学第二附属医院收治的子宫内膜异位症患者90例作为研究对象，根据随机数字表法将患者分为对照组和治疗组，每组各45例。对照组于月经来潮第1天肌肉注射注射用醋酸曲普瑞林，1支/次，1次/4周。治疗组在对照组治疗的基础上口服大黄蛰虫胶囊，0.9 g/次，2次/d。两组患者均持续治疗12周。观察两组患者的临床疗效，比较两组治疗前后囊肿直径、视觉模拟（VAS）评分、血液流变学指标和血清细胞因子水平。结果 治疗后，对照组和治疗组的总有效率分别为75.56%、91.11%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者VAS评分显著降低、囊肿直径显著缩小，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组上述指标均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组全血高切黏度、血浆比黏度、红细胞聚集指数、纤维蛋白原水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组血液流变学指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清基质金属蛋白酶-3（MMP-3）、血管内皮生长因子（VEGF）、转化生长因子-β1（TGF-β1）、白细胞介素-8（IL-8）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组血清细胞因子水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 大黄蛰虫胶囊联合注射用醋酸曲普瑞林治疗子宫内膜异位症疗效确切，能改善患者血液流变学指标和血清细胞因子水平，减轻疼痛，缩小异位病灶体积，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Dahuang Zhechong Capsules combined with Triptorelin Acetate for injection in treatment of endometriosis. Methods Patients (90 cases) with endometriosis in the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2017 to February 2018 were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were im administered with Triptorelin Acetate for injection at the first day of menstruation, 1 tube/time, once every 4 weeks. Patients in the treatment group were po administered with Dahuang Zhechong Capsules on the basis of the control group, 0.9 g/time, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, the cyst diameter, the VAS score, hemorheological indexes, and the serum cytokine levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 75.56% and 91.11%, respectively, and there were differences between two groups (P < 0.05). After treatment, the VAS scores in two groups were significantly reduced, and the cyst diameters were significantly decreased, and there were differences in the same group (P < 0.05). And these indexes in the treatment group were significantly lower than those in the control group (P < 0.05) After treatment, the levels of whole blood viscosity, plasma viscosity, erythrocyte aggregation index, and fibrinogen in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the levels of hemorheological indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, MMP-3, VEGF, TGF-β1 and IL-8 levels in two groups were significantly decreased, and there were differences in the same group (P < 0.05). And the serum cytokine levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Dahuang Zhechong Capsules combined with Triptorelin Acetate for injection has significant clinical effect in treatment of endometriosis, can improve hemorheological indexes and the serum cytokine levels, relieve the pain, and reduce the volume of ectopic lesions, which has a certain clinical application value.