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[摘要]
目的 探讨丹莪妇康煎膏联合曲普瑞林治疗卵巢巧克力囊肿的临床效果。方法 选取2015年6月-2017年6月荆州市中医医院收治的90例卵巢巧克力囊肿患者,随机分为对照组和治疗组,每组各45例。对照组于术后首次月经来潮第1天单次肌内注射注射用醋酸曲普瑞林3.75 mg。治疗组在对照组治疗基础上于术后首次月经来潮前第10天开始口服丹莪妇康煎膏,15 g/次,2次/d,连服14 d。两组均连续治疗6个月经周期,并随访6个月。观察两组的临床疗效,比较两组治疗前后视觉模拟评分法(VAS)评分、性激素指标、子宫动脉血流参数、血清指标水平及复发情况。结果 治疗后,对照组和治疗组的总有效率分别为82.2%、95.6%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组VAS评分、雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、收缩期峰值流速/舒张末期流速比值(S/D)、阻力指数(RI)和搏动指数(PI)、糖类抗原125(CA125)、肿瘤坏死因子(TNF)-α、核因子κB(NF-κB)、前列腺素F2α(PGF2α)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组VAS评分、E2、FSH、LH、S/D、RI、PI值、CA125、TNF-α、NF-κB、PGF2α水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。随访6个月,对照组和治疗组的复发率分别是22.2%、6.7%,两组比较差异具有统计学意义(P<0.05)。结论 丹莪妇康煎膏联合曲普瑞林治疗卵巢巧克力囊肿具有较好的临床疗效,能有效减轻患者症状,调节内分泌激素水平,改善微循环及子宫局部血流状态,减少复发,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Dan'e Fukang Soft Extracts combined with triptorelin in treatment of ovarian chocolate cyst. Methods Patients (90 cases) with ovarian chocolate cyst in Jingzhou Hospital of Traditional Chinese Medicine from June 2015 to June 2017 were randomly divided into control (45 cases) and treatment (45 cases) groups. Patients in the control group were im administered with Triptorelin acetate for injection 3.75 mg on day 1 of first postoperative menstruation. Patients in the treatment group were po administered with Dan'e Fukang Soft Extracts on the tenth day before the first menstruation after the operation on the basis of the control group, 15 g/time, twice daily, for 14 d. Patients in two groups were treated for 6 menstrual cycles, and were followed up for 6 months. After treatment, the clinical efficacy was evaluated, and the changes of VAS scores, sex hormones, uterine arterial blood flow parameters, serum levels and recurrence in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment group were 82.2% and 95.6%, and there were differences between two groups (P < 0.05). After treatment, VAS score, E2, FSH, LH, S/D, RI, PI, CA125, TNF-α, NF-κB, and PGF2α were significantly decreased in two groups, and there were differences in the same group (P < 0.05). After treatment, VAS score, E2, FSH, LH, S/D, RI, PI, CA125, TNF-α, NF-κB, and PGF2α in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). Follow up for 6 months, the recurrence rates in the control and treatment group were 22.2% and 6.7%, and there were differences between two groups (P < 0.05). Conclusion Dan'e Fukang Soft Extracts combined with triptorelin has significant clinical effect in treatment of ovarian chocolate cyst, and can effectively reduce symptoms, regulate hormone levels, and also can improve microcirculation and local uterine blood flow, and reduce recurrence, which has a certain clinical application value.
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