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[摘要]
目的 研究口腔溃疡散联合甲硝唑口腔粘贴片治疗复发性口腔溃疡的临床疗效。方法 选取2015年12月-2017年12月解放军第二五四医院诊治的复发性口腔溃疡患者100例为研究对象,将所有患者随机分为对照组和治疗组,每组各50例。对照组患者饭后使用甲硝唑口腔粘贴片,用棉签擦干黏膜后,粘附于口腔患处,1片/次,3次/d。治疗组在对照组治疗的基础上给予口腔溃疡散,用消毒棉球蘸取适量药物擦于患处,3次/d。7 d为1个疗程,两组持续治疗2个疗程。观察两组患者临床疗效,比较两组治疗前后的临床症状、视觉模拟量表(VAS)评分、炎性因子水平和复发情况。结果 治疗后,对照组和治疗组的临床总有效率分别为84.00%、96.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组者口腔溃疡数目、口腔溃疡直径、症状消失时间和溃疡愈合时间显著优于对照组,两组差异具有统计学意义(P<0.05)。治疗后,两组患者VAS评分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组治疗后VAS评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者TNF-α和IL-6水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组炎性因子水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组患者复发率为24.00%,显著高于治疗组的8.00%;治疗后,对照组复发间隔时间为(12.26±3.45)d,显著短于治疗组的(30.28±8.56)d,两组比较差异具有统计学意义(P<0.05)。结论 口腔溃疡散联合甲硝唑口腔粘贴片治疗复发性口腔溃疡具有较好的临床疗效,可改善患者口腔溃疡大小和数目、VAS疼痛评分,显著降低炎性因子水平,安全性较高,值得临床推广。
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[Abstract]
Objective To study the clinical effects of Kouqiang Kuiyang Powder combined with Metronidazole Oral Sticking Patches in treatment of recurrent aphtha. Methods Patients (100 cases) with recurrent aphtha in the 254th Hospital of the PLA from December 2015 to December 2017 were randomly divided into control group and treatment group, and each group had 50 cases. Patients in the control group were administered with Metronidazole Oral Sticking Patches after meals, then adhered Metronidazole Oral Sticking Patches to the wound after wiping the mucosa with a cotton swab, 1 piece/time, three times daily. Patients in the treatment group were given Kouqiang Kuiyang Powder on the basis of the control group, which was applied to the wound with a sterile cotton ball, three times daily. A course of treatment had 7 d, and patients in two groups were treated for 2 courses. After treatment, the clinical efficacies were evaluated, and the clinical symptoms, VAS scores, the inflammatory factors levels, and the relapse in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.00% and 96.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, the number of aphtha, diameter of aphtha, symptoms disappeared time, and the ulcer healing time in the treatment group were significantly better than those in the control group, and there was difference between two groups (P < 0.05). After treatment, VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the relapses rate in the control group was 24.00%, which was significantly higher than 8.00% in the treatment group (P < 0.05). After treatment, the interval of the relapse in the control group was (12.26 ±3.45), which was significantly shorter than (30.28 ±8.56) in the treatment group (P < 0.05). Conclusion Kouqiang Kuiyang Powder combined with Metronidazole Oral Sticking Patches has significant clinical effect in treatment of recurrent aphtha, can improve the size and number of aphtha, and improve the VAS scores, significantly reduce the level of inflammatory factors, with good safety, which has a certain clinical application value.
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