目的 探讨牛黄宁宫片联合氨磺必利治疗精神分裂症的临床疗效。方法 选取2017年2月-2017年11月在武威市红十字精神病院进行诊治的94例精神分裂症患者，根据用药差别分为对照组和治疗组，每组各47例。对照组口服氨磺必利片，0.4 g/次，1次/d；治疗组在对照组基础上口服牛黄宁宫片，6片/次，3次/d。两组均连续治疗2个月。观察两组的临床疗效，比较两组治疗前后PANSS评分、HAMD评分、GQOLI-74评分、血清学指标的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是80.85%、95.74%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗后，两组PANSS评分、HAMD评分较治疗前均显著降低，GQOLI-74评分显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组PANSS评分、HAMD评分低于对照组，GQOLI-74评分高于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清神经元特异性烯醇化酶（NSE）、S100β蛋白、白细胞介素-1β（IL-1β）、高迁移率族蛋白B1（HMGBl）水平均较治疗前显著降低，但胶质源性神经营养因子（GDNF）水平均显著增高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组NSE、S100β蛋白、IL-1β、HMGBl低于对照组，GDNF水平高于对照组，两组比较差异有统计学意义（P<0.05）。结论 牛黄宁宫片联合氨磺必利治疗精神分裂症具有较好的临床疗效，可有效改善患者症状体征，提高患者生活质量，调节血清学指标，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Niuhuang Ningong Tablets combined with amisulpride in treatment of schizophrenia. Methods Patients (94 cases) with schizophrenia in Wuwei Red Cross Psychiatric Hospital from February 2017 to November 2017 were divided into control (47 cases) and treatment (47 cases) groups according to the difference of treatment. Patients in the control group were po administered with Amisulpride Tablets, 0.4 g/time, once daily. Patients in the treatment group were po administered with Niuhuang Ningong Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the changes of PANSS score, HAMD score, GQOLI-74 score, and serological indicators in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 80.85% and 95.74%, and there were differences between two groups (P < 0.05). After treatment, PANSS score and HAMD score were significantly decreased, but GQOLI-74 score was significantly increased, and there were differences in the same group (P < 0.05). After treatment, PANSS score and HAMD score were lower than those in the control group, but GQOLI-74 score was higher than that in the control group, and there were differences between two groups (P < 0.05). After treatment, NSE, S100β protein, IL-1β, and HMGBl were significantly decreased, but GDNF score was significantly increased, and there were differences in the same group (P < 0.05). After treatment, NSE, S100β protein, IL-1β, and HMGBl were lower than those in the control group, but GDNF score was higher than that in the control group, and there were differences between two groups (P < 0.05). Conclusion Niuhuang Ningong Tablets combined with amisulpride has significant clinical effect in treatment of schizophrenia, and can effectively improve symptoms and signs, and also can improve life quality, and regulate serological indicators, which has a certain clinical application value.