结直肠癌是严重威胁人们健康的重大疾病。结直肠癌常用化疗药物5-氟尿嘧啶、卡培他滨、奥沙利铂的心脏毒性机制更复杂，临床表现更具变异性。5-氟尿嘧啶可引发从心绞痛到致命性心肌梗死的冠状动脉痉挛，其前体药物卡培他滨在带来用药便利的同时，亦存在直接心肌损伤的风险，而奥沙利铂所致严重心律失常的病例报告也提示其心脏安全性不容忽视。总结了结直肠癌常用化疗药物5-氟尿嘧啶、卡培他滨、奥沙利铂的心脏毒性特征和机制，探讨了心脏毒性的全程监测和干预策略，为提升结直肠癌化疗相关心脏毒性的防控水平提供循证依据和思路借鉴。

Colorectal cancer is a major disease that seriously threatens people’s health. The cardiotoxicity mechanisms of commonly used chemotherapy drugs for colorectal cancer, such as 5-fluorouracil, capecitabine, and oxaliplatin, are more complex and the clinical manifestations are more variable. 5-Fluorouracil can cause coronary artery spasms ranging from angina to fatal myocardial infarction. While its precursor drug capecitabine brings convenience to medication, there is also a risk of direct myocardial damage. Case reports of severe arrhythmia caused by oxaliplatin also suggest that its cardiac safety cannot be ignored. This article summarizes the cardiotoxicity characteristics and mechanisms of commonly used chemotherapy drugs for colorectal cancer, including 5-fluorouracil, capecitabine, and oxaliplatin. It explores the full monitoring and intervention strategies for cardiotoxicity, providing evidence-based evidence and reference for improving the prevention and control of chemotherapy related cardiotoxicity in colorectal cancer.

R979.1

中国金属学会冶金安全与健康分会健康卫生科研项目(jkws202304); 包头市卫生健康科技计划项目(Wsjkkj2022078)