心血管疾病的发生、发展涉及脂质代谢紊乱、血管内皮功能障碍、慢性炎症反应、氧化应激、血栓形成等多种病理机制，具有致残率高、致死率高、疾病负担重等特点。儿茶素可通过改善血管内皮舒缩功能、减轻炎性损伤、减轻脂质过氧化反应、减轻心肌细胞程序性死亡、抑制动脉粥样硬化形成、降低血压对心血管疾病发挥防治作用。总结了儿茶素治疗心血管疾病的药理作用研究进展，为儿茶素的临床应用提供参考。

The occurrence and progression of cardiovascular diseases involve various pathological mechanisms such as lipid metabolism disorders, vascular endothelial dysfunction, chronic inflammatory responses, oxidative stress, and thrombosis, characterized by high disability and mortality rates, and heavy disease burden. Catechin can play preventive and therapeutic role in cardiovascular diseases by improving vascular endothelial vasomotor function, alleviating inflammatory damage, reducing lipid peroxidation, mitigating myocardial cell programmed death, inhibiting atherosclerosis formation, and lowering blood pressure. This article summarizes the pharmacological research progress of catechin in treating cardiovascular diseases, providing a reference for their clinical application.

R286.2

邢台市科技计划项目(2017ZC058)