糖尿病肾病是糖尿病最常见且最严重的慢性并发症之一，当前临床治疗主要依赖血糖和血压控制药物。人参皂苷Rg₁是来源于五加科植物人参及其同属植物根部中的主要活性成分之一，可通过减轻炎性损伤、减轻氧化损伤、减轻脂质毒性损伤、抑制肾组织细胞凋亡、抑制肾组织纤维化发挥治疗糖尿病肾病的作用。综述了人参皂苷Rg1治疗糖尿病肾病的药理作用研究进展，为人参皂苷Rg1治疗糖尿病肾病的临床应用提供参考。

Diabetes nephropathy is one of the most common and serious chronic complications of diabetes. At present, the clinical treatment of diabetes nephropathy mainly depends on blood sugar and blood pressure control drugs. Ginsenoside Rg₁ is one of the main active ingredients derived from the roots of Panax ginseng and other plants in the Araliaceae family. Ginsenoside Rg₁ can play a role in treatment of diabetes nephropathy by reducing inflammatory damage, reducing oxidative damage, reducing lipid toxicity damage, inhibiting renal tissue apoptosis, and inhibiting renal tissue fibrosis. This article reviews the pharmacological effects of ginsenoside Rg₁ in treatment of diabetes nephropathy, providing a reference for the clinical application of ginsenoside Rg₁ in treatment of diabetes nephropathy.

R974

保定市社发类项目(S20230043)