呼吸系统疾病的类型多样，主要包括感染性肺炎、慢性气道疾病、间质性肺疾病等，可造成不同程度的通气和换气功能障碍。目前临床治疗主要依赖抗感染药物、支气管扩张剂、糖皮质激素、抗纤维化药物、分子靶向或免疫调节药物等。大黄素是从大黄、虎杖、何首乌等多种蓼科药用植物的根及根茎中提取的蒽醌类活性成分，可通过抗病毒、抗菌、降低病原菌耐药性、减轻气道炎症反应、减轻气道高反应性、减轻氧化应激反应、减轻气道重塑、减轻肺组织细胞凋亡防治呼吸系统疾病。总结了大黄素防治呼吸系统疾病的药理作用研究进展，为大黄素治疗呼吸系统疾病的临床研究提供支持。

There are various types of respiratory diseases, mainly including infectious pneumonia, chronic airway diseases, interstitial lung diseases, etc. They can cause varying degrees of ventilation and respiratory dysfunction. At present, clinical treatment drugs mainly rely on anti-infective drugs, bronchodilators, glucocorticoids, anti-fibrotic drugs, molecular targeted or immunomodulatory drugs, etc. Emodin is an anthraquinone active ingredient extracted from the roots and rhizomes of various medicinal plants in the Polygonaceae family, such as Rhei Radix et Rhizoma, Polygoni Cuspidati Rhizomaet Radix, and Polygni Multiflori Radix. Emodin can prevent and treat respiratory diseases by antiviral, antibacterial, reducing pathogen resistance, alleviating airway inflammation, reducing airway hyperresponsiveness, alleviating oxidative stress response, reducing airway remodeling, and alleviating lung tissue cell apoptosis. This article summarizes the research progress on pharmacological effects of emodin in prevention and treatment of respiratory diseases, providing support for clinical research on the treatment of respiratory diseases with emodin.

R286.4

山东省中医药科技项目(M-2022096)