中枢神经系统疾病可能对中枢神经造成不可逆的损伤或引发慢性病变。原儿茶酸是一种天然酚酸类化合物，可通过多种机制防治阿尔茨海默病、帕金森病、缺氧缺血性脑病、记忆和认知功能障碍、抑郁症等中枢神经系统疾病。综述了原儿茶酸防治中枢神经系统疾病的研究进展，为中枢神经系统疾病的临床防治提供理论支撑。

Central nervous system disorders may cause irreversible damage or trigger chronic lesions in the central nervous system. Protocatechuic acid, a natural phenolic acid compound, can prevent and treat various central nervous system diseases such as Alzheimer's disease, Parkinson's disease, hypoxic-ischemic brain damage, memory and cognitive dysfunction, and depression through multiple mechanisms. This article reviews the research progress of protocatechuic acid in prevention and treatment of central nervous system diseases, providing theoretical support for their clinical management.

R971

中国博士后科学基金资助课题(2015M581496); 黑龙江省自然科学基金联合引导项目(LH2022H068); 黑龙江省中医药科研课题(ZHY2025-180); 黑龙江省卫生健康委科研课题(20220202080996); 黑龙江中医药大学研究生创新科研项目(2022yjscx012,2019yjscx011,2024yjsc027)