目的 探讨孕康糖浆联合盐酸利托君片治疗先兆流产的临床疗效。方法 选取上海市嘉定区南翔医院在2023年3月—2025年12月收治的先兆流产患者共80例，以随机数字表法分为对照组和治疗组，每组40例。对照组患者口服盐酸利托君片，首日1片/2 h，次日2片/6 h，维持剂量3片/次，3次/d。治疗组患者在对照组治疗的基础上空腹服用孕康糖浆，20 mL/次，3次/d。患者连续治疗2周统计疗效。比较两组的治疗效果、症状消失时间、动脉血流动力学、血清指标。结果 治疗组总有效率为97.50%，明显高于对照组的82.50%，组间差异显著（P＜0.05）。治疗组患者腰酸痛、下腹痛、阴道出血、宫缩消失时间均明显短于对照组（P＜0.05）。两组治疗后的子宫螺旋动脉搏动指数（PI）、阻力指数（RI）、收缩期峰值流速与舒张末期流速比值（S/D）显著降低（P＜0.05），治疗组的PI、RI、S/D均明显低于对照组（P＜0.05）。两组治疗后的D-二聚体（D-D）、同型半胱氨酸（Hcy）明显降低，纤溶酶原（PLG）明显升高（P＜0.05）；治疗组治疗后的D-D、Hcy低于对照组，PLG高于对照组（P＜0.05）。结论 孕康糖浆联合盐酸利托君片可提高先兆流产的临床疗效，减轻临床症状，改善子宫动脉血流动力学水平和凝血功能。

Objective To investigate the clinical efficacy of Yunkang Syrup combined with Ritodrine Hydrochloride Tablets in treatment of threatened abortion. Methods 80 Patients with threatened abortion admitted to Shanghai Jiading Nanxiang Hospital from March 2023 to December 2025 were divided into control group and treatment group using a random number table method, with 40 patients in each group. The control group patients were orally administered with Ritodrine Hydrochloride Tablets, with a dose of 1 tablet/2 h on the first day and 2 tablets/6 h on the second day, and a maintenance dose of 3 tablets/time, 3 times daily. The treatment group received fasting administration of Yunkang Syrup on the basis of treatment in the control group, 20 mL/time, 3 times daily. The efficacy of the treatment was recorded for 2 consecutive weeks. The treatment efficacy, symptom disappearance time, arterial hemodynamics, and serum indicators between two groups were compared. Results The total effective rate of the treatment group was 97.50%, significantly higher than the control group's total effective rate 82.50%, and the difference between the groups was significant (P < 0.05). The disappearance time of waist pain, lower abdominal pain, vaginal bleeding, and uterine contractions in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the pulsatility index (PI), resistance index (RI), and peak systolic velocity to end diastolic velocity ratio (S/D) of the uterine spiral artery in two groups were significantly reduced (P < 0.05). The PI, RI, and S/D of the treatment group were significantly lower than those of the control group (P < 0.05). After treatment, D-dimer (D-D) and homocysteine (Hcy) levels were significantly reduced in two groups, while plasminogen (PLG) levels were significantly increased (P < 0.05). The D-D and Hcy levels in the treatment group were lower than those in the control group, while PLG levels were higher than those in the control group (P < 0.05). Conclusion The combination of Yunkang Syrup and Ritodrine Hydrochloride Tablets can improve the clinical efficacy of threatened abortion, alleviate clinical symptoms, and improve uterine artery hemodynamics and coagulation function.

R984

上海市嘉定区卫生健康委员会科研课题(2019-QN-11)