抑郁症长期存在可显著降低患者生活质量，其病理机制复杂，整体治疗仍面临较大难度。人参皂苷Rb₁是从人参中分离得到的四环三萜皂苷，具有多重作用，可通过减轻神经炎症反应、减轻氧化应激反应、抑制下丘脑-垂体-肾上腺轴亢进、抑制神经细胞凋亡、调节单胺神经递质的分泌、增强神经可塑性发挥抗抑郁作用。总结了人参皂苷Rb₁治疗抑郁症的药理作用研究进展，为人参皂苷Rb₁应用提供支持。

The long-term presence of depression can significantly reduce patients’ quality of life, with complex pathological mechanisms, making comprehensive treatment still quite challenging. Ginsenoside Rb₁, a tetracyclic triterpenoid saponin isolated from Ginseng Radix, exhibits multiple effects. It exerts antidepressant effects by alleviating neuroinflammation, mitigating oxidative stress, inhibiting hyperactivity of the hypothalamic-pituitary-adrenal axis, suppressing neuronal apoptosis, regulating monoamine neurotransmitter secretion, and enhancing neuroplasticity. This article summarizes the pharmacological research progress on ginsenoside Rb₁ in treatment of depression, providing support for its application.

R971

国家重点研发计划（2017YFC1310100）