目的 探讨消痛贴膏联合洛索洛芬钠片治疗肩周炎的临床疗效。方法 选取2023年8月—2025年8月在长沙市第三医院就诊的99例肩周炎患者，按随机数字表法将患者分为对照组（49例）和治疗组（50例）。对照组口服洛索洛芬钠片60 mg/次，3次/d。治疗组在对照组基础上使用消痛贴膏，每次1贴，1次/d。所有患者持续治疗8周。观察患者的治愈率、肩关节功能、疼痛程度和血清指标。结果 对照组的治愈率为61.22%，治疗组的治愈率为80.00%，组间差异显著（P＜0.05）。治疗后，两组的疼痛、日常生活、关节活动度、肌力评分均高于治疗前（P＜0.05），且治疗组的中文版Constant-Murley肩关节评分量表（CMS）各部分评分均高于对照组（P＜0.05）。治疗后，两组的疼痛描述词、现时疼痛程度、VAS评分均低于治疗前（P＜0.05），且治疗组简式McGill疼痛问卷（SF-MPQ）各部分评分低于对照组（P＜0.05）。治疗后，两组的三角肌表面积分肌电值（iEMG）明显升高（P＜0.05），且组间以治疗组iEMG更高（P＜0.05）。治疗后，两组的血清白细胞介素-18（IL-18）、肿瘤坏死因子-α（TNF-α）、一氧化氮（NO）水平均明显降低（P＜0.05），且组间比较以治疗组治疗后的血清IL-18、TNF-α、NO水平更低（P＜0.05）。结论 消痛贴膏联合洛索洛芬钠片可提高肩周炎的疗效，改善肩关节功能和减轻疼痛程度，提高三角肌功能，机制与降低炎症反应有关。

Objective To explore the clinical efficacy of Xiaotong Plaster combined with Loxoprofen Sodium Tablets in treatment of shoulder periarthritis. Methods 99 Patients with shoulder periarthritis who visited Changsha Third Hospital from August 2023 to August 2025 were selected and divided into control group (49 cases) and treatment group (50 cases) using a random number table method. The control group was orally administered Loxoprofen Sodium Tablets 60 mg/time, 3 times daily. The treatment group received Xiaotong Plaster on the basis of the control group, 1 patch per time, once daily. The patients were treated for 8 weeks. The cure rate, shoulder joint function, pain level, and serum indicators were compared between two groups of patients. Results The cure rate of the control group was 61.22%, while the cure rate of the treatment group was 80.00%, with a significant difference between two groups (P< 0.05). After treatment, the scores of pain, daily life, joint mobility, and muscle strength of two groups increased (P < 0.05), and all parts in the Chinese version of the Constant-Murley Shoulder Score Scale (CMS) in the treatment group were higher than those scores than the control group (P< 0.05). After treatment, the pain descriptors, current pain severity, and VAS scores of two groups decreased (P < 0.05), and the scores of each part of the Short-form McGill Pain Questionnaire (SF-MPQ) in the treatment group were lower than those in the control group (P < 0.05). After treatment, the surface area electromyography (iEMG) of the deltoid muscle in two groups significantly increased (P < 0.05), and the iEMG of the treatment group was higher than that of the control group (P < 0.05). After treatment, the serum levels of interleukin-18 (IL-18), tumor necrosis factor-α (TNF-α), and nitric oxide (NO) in two groups were significantly reduced (P < 0.05), and the serum levels of IL-18, TNF-α, and NO in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Xiaotong Plaster and Loxoprofen Sodium Tablets can enhance the efficacy in treatment of shoulder periarthritis, improve shoulder joint function, reduce pain levels, and enhance deltoid function, with the mechanism related to the reduction of inflammatory responses.

R982

湖南创新型省份建设专项（2025JJ81111）