目的 探讨疏血通注射液联合注射用己酮可可碱治疗下肢深静脉血栓的疗效。方法 选取2023年2月—2026年1月在沧州市人民医院治疗的下肢深静脉血栓患者共102例，所有患者以随机数字表法分为对照组和治疗组，各包括51例。对照组静脉滴注注射用己酮可可碱，0.1 g/次，1次/d。治疗组在对照组患者的基础上静脉滴注疏血通注射液，每次6 mL加入300 mL生理盐水，1次/d。两组持续15 d治疗。比较两组的治疗效果、疼痛程度、超声指标、血清指标。结果 对照组的总有效率为80.39%，治疗组的为94.12%，组间有明显差异（P＜0.05）。两组治疗后患肢的VAS评分低于治疗前（P＜0.05），且治疗组治疗后患肢的VAS评分明显低于对照组（P＜0.05）。治疗后，两组的血栓长度、双下肢周径差明显低于治疗前，血流速度明显高于治疗前（P＜0.05）；治疗组治疗后的血栓长度、双下肢周径差明显低于对照组，血流速度明显高于对照组（P＜0.05）。两组治疗后的P-选择素、D-二聚体、凝血酶-抗凝血酶复合物明显低于治疗前（P＜0.05）；治疗组治疗后的P-选择素、D-二聚体、凝血酶-抗凝血酶复合物明显低于对照组（P＜0.05）。结论 疏血通注射液联合注射用己酮可可碱可提高下肢深静脉血栓的疗效，减轻疼痛程度和血栓严重程度，有助于阻止血栓形成。

Objective To investigate the efficacy of Shuxuetong Injection combined with Pentoxifylline for injection in treatment of lower limb deep venous thrombosis. Methods 102 Patients with lower limb deep vein thrombosis treated at Cangzhou People’s Hospital from February 2023 to January 2026 were divided into control group and treatment group using a random number table method, with 51 patients in each group. The control group received intravenous infusion of Pentoxifylline for injection at a dose of 0.1 g/time, once daily. The treatment group received intravenous infusion of Shuxuetong Injection on the basis of the control group, with 6 mL added to 300 mL physiological saline each time, once daily. Two groups were treated continuously for 15 days. The treatment effects, pain levels, ultrasound indicators, and serum indicators of two groups were compared. Results The total effective rate of the control group was 80.39%, the total effective rate of the treatment group was 94.12%, and there was a significant difference between two groups (P < 0.05). After treatment, the VAS scores of the affected limbs in two groups decreased (P< 0.05), and the VAS scores of the affected limbs in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the thrombus length and the difference in circumference and diameter between two lower limbs were significantly reduced in two groups, while the blood flow velocity was significantly increased (P < 0.05). After treatment, the thrombus length and the difference in circumference and diameter between two lower limbs in the treatment group were significantly reduced, while the blood flow velocity was significantly increased (P< 0.05). After treatment, the levels of p-selectin, D-dimer, and thrombin antithrombin complex in two groups were significantly reduced (P< 0.05), and the levels of p-selectin, D-dimer, and thrombin antithrombin complex in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion The combination of Shuxuetong Injection and Pentoxifylline for injection can improve the clinical efficacy of lower limb deep vein thrombosis, reduce pain and thrombus severity, and help prevent thrombus formation.

R972

河北省医学科学研究课题计划（20240527）