目的 探寻脉管复康胶囊与己酮可可碱缓释片联合治疗血栓闭塞性脉管炎的临床疗效。方法 选取2024年1月—2025年1月唐山市中医医院收治的61例血栓闭塞性脉管炎患者，依据治疗方式不同分为对照组（30例）和治疗组（31例）。对照组餐后服用己酮可可碱缓释片，1粒/次，2次/d。治疗组在对照组治疗基础上给予口服脉管复康胶囊，1.8 g/次，3次/d。两组均连续治疗1个月。观察两组的临床疗效，比较两组临床症状评分、踝肱指数、血清炎症因子水平、氧化应激与纤溶系统指标。结果 治疗组总有效率是96.67%，显著高于对照组的76.67%（P＜0.05）。治疗后两组间歇性跛行评分、静息痛评分、肢体麻木评分低于同组治疗前，踝肱指数高于同组治疗前（P＜0.05）；且治疗组间歇性跛行评分、静息痛评分、肢体麻木评分均低于对照组，而踝肱指数高于对照组（P＜0.05）。治疗后两组血清高敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、同型半胱氨酸（Hcy）均低于同组治疗前（P＜0.05），且治疗后治疗组血清hs-CRP、IL-6、Hcy均低于对照组（P＜0.05）。治疗后两组血清超氧化物歧化酶（SOD）、一氧化氮（NO）、及组织型纤溶酶原激活物（t-PA）均高于同组治疗前（P＜0.05），且治疗后治疗组血清SOD、NO、t-PA均高于对照组（P＜0.05）。结论 脉管复康胶囊联合己酮可可碱治疗血栓闭塞性脉管炎患者的临床效果较好，该联合策略通过促进血液循环、缓解炎症状态及对抗氧化应激等多靶点干预，实现了疗效的增效，对指导血栓闭塞性脉管炎的临床实践具有重要意义。

Objective To explore the clinical efficacy of Maiguan Fukang Capsules combined with Pentoxifylline Sustained Release Tablets in treatment of thromboangiitis obliterans. Methods Sixty-one patients with thromboangiitis obliterans who were admitted to Tangshan Traditional Chinese Medicine Hospital from January 2024 to January 2025 were selected. They were divided into control group (30 cases) and treatment group (31 cases) based on different treatment methods. Patients in control group took Pentoxifylline Sustained Release Tablets after meals, 1 tablet each time, twice daily. Patients in treatment group were po administered with Maiguan Fukang Capsules on the basis of control group, 1.8 g each time, 3 times daily. Both groups were treated continuously for 1 month. The clinical efficacy of two groups was observed, and the clinical symptom scores, ankle-brachial index, serum inflammatory factor levels, oxidative stress and fibrinolytic system indicators were compared between two groups. Results The total effective rate of treatment group was 96.67%, significantly higher than that of control group (76.67%), (P < 0.05). After treatment, the intermittent claudication score, resting pain score, and limb numbness score of both groups were lower than those before treatment in the same group, and ankle-brachial index was higher than that before treatment in the same group (P < 0.05), and the intermittent claudication score, resting pain score, and limb numbness score of treatment group were lower than those of control group, while the ankle-brachial index was higher than that of the control group (P < 0.05). After treatment, hs-CRP, IL-6, and Hcy of both groups were lower than those before treatment in the same group (P< 0.05), and the serum hs-CRP, IL-6, and Hcy of treatment group were lower than those of the control group after treatment (P < 0.05). After treatment, the serum SOD, NO, and t-PA of both groups were higher than those before treatment in the same group (P < 0.05), and the serum SOD, NO, and t-PA of treatment group were higher than those of control group after treatment (P < 0.05). Conclusion The clinical effect of Maiguan Fukang Capsules combined with pentoxifylline in treatment of thromboangiitis obliterans is quite good. This combined strategy achieves enhanced efficacy through multiple-target interventions such as promoting blood circulation, alleviating inflammatory conditions, and combating oxidative stress, which is of great significance for guiding clinical practice in thromboangiitis obliterans.

R972

河北省中医药类科研课题项目（2025513）