[关键词]
[摘要]
乳腺癌是一类起源于乳腺上皮组织的高度异质性恶性肿瘤,不同分子分型乳腺癌在治疗中面临显著挑战,亟需开发具有多靶点调控的新型干预策略。隐丹参酮可通过抑制细胞增殖、阻止细胞侵袭和转移、诱导细胞凋亡、降低细胞多药耐药性、增强化疗敏感性、调节免疫功能限制乳腺癌的肿瘤生长,发挥强效抗肿瘤作用。总结了隐丹参酮防治乳腺癌的药理作用研究进展,为隐丹参酮的临床应用提供循证支持。
[Key word]
[Abstract]
Breast cancer is a kind of highly heterogeneous malignant tumor originating from breast epithelial tissue. Different molecular types of breast cancer face significant challenges in the treatment. It is urgent to develop new intervention strategies with multi target regulation. Cryptotanshinone can play a powerful anti-tumor role to limit the growth of breast cancer by inhibiting cell proliferation, preventing cell invasion and metastasis, inducing cell apoptosis, reducing cell multidrug resistance, enhancing chemotherapy sensitivity, and regulating immune function. This article summarized the research progress of pharmacological action of cryptotanshinone in preventing and treating breast cancer, providing evidence-based support for the clinical application of cryptotanshinone.
[中图分类号]
R285.5;R979.1
[基金项目]