代谢相关脂肪性肝病已成为全球范围内发病率最高的慢性肝脏疾病，但单一靶点药物往往难以阻断复杂的病理级联反应。葛根素可通过改善脂质代谢、减轻胰岛素抵抗、减轻炎症反应、减轻氧化应激反应、抑制肝细胞死亡、抑制糖异生进程、抑制肝纤维化、调控肠道菌群、促进肝细胞自噬发挥防治代谢相关脂肪性肝病的作用，以延缓病理进展。总结了葛根素防治代谢相关脂肪性肝病的药理作用研究进展，以期为葛根素的临床应用提供参考。

The metabolic dysfunction-associated fatty liver disease has become the most prevalent chronic liver disease globally, but single-target drugs often struggle to block the complex pathological cascade reactions. Puerarin can play a role in prevention and treatment of metabolic dysfunction-associated fatty liver disease by improving lipid metabolism, alleviating insulin resistance, reducing inflammatory responses, mitigating oxidative stress, inhibiting hepatocyte death, suppressing gluconeogenesis, preventing liver fibrosis, regulating gut microbiota, and promoting hepatocyte autophagy, thereby delaying pathological progression. This article summarizes the pharmacological research progress on puerarin’s effects in preventing and treating metabolic dysfunction-associated fatty liver disease, aiming to provide a reference for the clinical application of puerarin.

R285.5;R975

甘肃省科技计划项目（22JR11RA064）