目的 探讨胜红清热胶囊联合左氧氟沙星治疗慢性盆腔炎的临床疗效。方法 选择2023年2月—2024年12月于三二〇一医院就诊的慢性盆腔炎患者126例，采用区组随机分配方式将患者分为对照组（63例）和治疗组（63例）。对照组患者口服盐酸左氧氟沙星片，100 mg/次，2次/d。治疗组在对照组基础上口服胜红清热胶囊，3～4粒/次，3次/d。两组患者连续服用2周。观察两组患者临床疗效，比较治疗前后两组患者临床症状好转时间，血清白细胞介素-1β（IL-1β）、IL-26、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）水平，及健康状况调查简表（SF-36）评分。结果 治疗后，治疗组临床总有效率为95.24%，明显高于对照组的82.54%（P＜0.05）。治疗后，治疗组患者下腹部疼痛消失时间、白带恢复正常时间、腰骶部胀痛消失时间和经期月经量多的好转时间均显著短于对照组（P＜0.05）。治疗后，两组患者血清IL-1β、IL-26、TNF-α及CRP浓度均显著下降，且治疗组的血清炎性因子水平明显低于对照组（P＜0.05）。治疗后，两组患者SF-36各项维度得分以及总分均呈显著上升，且治疗组SF-36评分显著高于对照组（P＜0.05）。结论 将胜红清热胶囊与盐酸左氧氟沙星片联合使用，可显著治疗慢性盆腔炎，缩短临床症状好转时间，降低血清炎性因子，提高生活质量，不良反应少。

Objective To investigate the therapeutic effectiveness of Shenghong Qingre Capsules combined with levofloxacin in treatment of chronic pelvic inflammatory disease. Methods Patients (126 cases) with chronic pelvic inflammatory disease in 3201 Hospital from February 2023 to December 2024 were divided into control (63 cases) and treatment (63 cases) group by method of block random allocation. Patients in control group were po administered with Levofloxacin Hydrochloride Tablets, 100 mg/time, twice daily. Patients in treatment group were po administered with Shenghong Qingre Capsules on the basis of the control group, 3 — 4 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical evaluations were evaluated, and the improvement time of clinical symptoms, serum inflammatory factor IL-1β, IL-26, TNF-α and CRP levels, and the SF-36 scores in two groups before and after treatment were compared. Results After treatment, the total clinical effective rate of the treatment group was 95.24%, which was significantly higher than that of the control group (82.54%, P < 0.05). Regarding the improvement of clinical symptoms, the treatment group had significantly shorter durations of lower abdominal pain disappearance, normal vaginal discharge recovery, lumbosacral distending pain disappearance, and excessive menstrual flow improvement than the control group (all P < 0.05). Regarding serum inflammatory factors, the concentrations of IL-1β, IL-26, TNF-α, and CRP in two groups were significantly decreased after treatment; notably, the levels of these factors in the treatment group were significantly lower than those in the control group (P < 0.05). Regarding quality of life, the scores of all dimensions and the total score of the 36-Item Short Form Health Survey (SF-36) in two groups was significantly increased after treatment, and those in the treatment group were significantly higher than those in the control group (P < 0.05). Conclusion The combination of Shenghong Qingre Capsules and Levofloxacin Hydrochloride Tablets can effectively treat chronic pelvic inflammatory disease, shorten the time for clinical symptom improvement, reduce serum inflammatory factors, improve quality of life, and have fewer adverse reactions.

R984

陕西省科学技术研究发展计划项目（22JR10RA271）