目的 评估厌食康颗粒和葡萄糖酸锌口服溶液联合治疗小儿厌食症的临床效果。方法 选取南京市中西医结合医院2025年1～8月收治的82例厌食症患儿为研究对象，采用随机数字表法将患儿分配至对照组和治疗组，每组41例。对照组口服葡萄糖酸锌口服溶液，年龄1～3岁，体质量10～15 kg，10～15 mL/d；年龄4～6岁，体质量16～21 kg，15～20 mL/d；年龄7～9岁，体质量22～27 kg，20～25 mL/d；年龄10～12岁，体质量28～32 kg，25～30 mL/d。治疗组在对照组的基础上开水冲服厌食康颗粒，1～6岁、1/2袋/次，7～12岁、1袋/次，3次/d。两组患儿均治疗2周。比较两组患儿的临床疗效、临床指标、胃肠功能指标。结果 治疗组的总有效率95.12%高于对照组的总有效率78.05%（P＜0.05）。治疗组的食欲恢复时间、胃排空1/2时间短于对照组，日摄食量大于对照组，身体质量指数（BMI）高于对照组（P＜0.05）。治疗后，两组血清胃泌素17（G-17）、胃动素（MTL）水平升高，血清胃饥饿素（GHR）、血管活性肠肽（VIP）水平降低（P＜0.05），且治疗组血清G-17、MTL水平高于对照组，血清GHR、VIP水平低于对照组（P＜0.05）。结论 厌食康颗粒联合葡萄糖酸锌口服溶液治疗小儿厌食症，可提高临床疗效，改善临床症状和胃肠功能指标。

Objective To evaluate the clinical effect of Yanshikang Granules combined with Zinc Gluconate Oral Solution in treatment of anorexia nervosa in children. Methods A total of 82 children with anorexia nervosa admitted to Nanjing Hospital of Integrated Traditional Chinese and Western Medicine from January to August 2025 were selected as the study subjects. The children were divided into control group and treatment group using a random number table, with 41 cases in each group. The control group was administered Zinc Gluconate Oral Solution: 10 — 15 mL/d for children aged 1 — 3 years (body weight 10 — 15 kg), 15 — 20 mL/d for those aged 4 — 6 years (body weight 16 — 21 kg), 20 — 25 mL/d for those aged 7 — 9 years (body weight 22 — 27 kg), and 25 — 30 mL/d for those aged 10 — 12 years (body weight 28 — 32 kg). The treatment group was po administered with Yanshikang Granules on the basis of the control group, half bag per time for children aged 1 — 6 years and 1 bag per time for those aged 7 — 12 years, three times daily. Two groups were treated for 2 weeks. The clinical efficacy, clinical indicators, and gastrointestinal function indicators were compared between two groups. Results The total clinical effective rate in the treatment group (95.12%) was significantly higher than 78.05% in the control group (P < 0.05). The treatment group exhibited shorter time to appetite recovery and gastric emptying half-time, higher daily food intake, and a greater body mass index (BMI) compared to the control group (P < 0.05). After treatment, the serum levels of gastrin 17 (G-17) and motilin (MTL) increased in two groups, while the serum levels of ghrelin (GHR) and vasoactive intestinal peptide (VIP) decreased (P < 0.05). The serum levels of G-17 and MTL in the treatment group were higher than those in the control group, while the serum levels of GHR and VIP were lower than those in the control group (P < 0.05). Conclusion Yanshikang Granules combined with Zinc Gluconate Oral Solution can improve the clinical efficacy, alleviate clinical symptoms and gastrointestinal function in treatment of anorexia nervosa in children.

R975

江苏省妇幼保健协会科研课题（FYX202311）