目的 探讨愈心痛胶囊联合阿托伐他汀钙片治疗冠心病心绞痛的临床疗效。方法 选取2024年6月—2025年8月在唐山市丰南区中医医院接受治疗的94例冠心病心绞痛患者为研究对象，采用随机数字表法将患者分为对照组和治疗组，每组各47例。对照组口服阿托伐他汀钙片，1片/次，1次/d。治疗组在对照组方案基础上加服愈心痛胶囊，4粒/次，3次/d。两组患者疗程均为8周。比较两组患者的临床疗效、心绞痛表现、Duke评分、中国心血管病人生活质量评定问卷（CQQC）评分、心肌酶指标、血清炎性因子。结果 治疗后，治疗组患者总有效率为91.49%，明显高于对照组的78.72%（P＜0.05）。治疗后，两组患者心绞痛视觉模拟量表（VAS）评分、时长、次数都降低（P＜0.05），且治疗组治疗后心绞痛VAS评分、时长、次数显著低于对照组（P＜0.05）。治疗后，两组Duke、中国心血管病人生活质量评定问卷（CQQC）评分均升高（P＜0.05），且治疗组治疗后Duke、CQQC评分明显高于对照组（P＜0.05）。两组患者治疗后血清肌酸激酶同工酶（CK-MB）、肌酸激酶（CK）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均显著降低（P＜0.05），且治疗组治疗后血清CK-MB、CK、IL-6、TNF-α水平均显著低于对照组（P＜0.05）。结论 愈心痛胶囊联合阿托伐他汀钙片治疗冠心病心绞痛的疗效显著，能改善预后、提升生活质量，降低心肌酶和炎性因子。

Objective To investigate the clinical efficacy of Yuxintong Capsules combined with Atorvastatin Calcium Tablets in treatment of angina pectoris in coronary heart disease. Methods A total of 94 patients with coronary heart disease and angina pectoris who received treatment at Tangshan Fengnan District Hospital of Traditional Chinese Medicine from June 2024 to August 2025 were selected as the research subjects. The patients were divided into control group and treatment group using a random number table method, with 47 patients in each group. The control group took Atorvastatin Calcium Tablets orally, 1 tablet/time, once daily. The treatment group also took Yuxintong Capsules in addition to the control group’s regimen, 4 capsules/time, 3 times daily. The treatment course for two groups of patients was 8 weeks. The clinical efficacy, angina symptoms, Duke score, Chinese Cardiovascular Quality of Life Questionnaire (CQQC) score, myocardial enzyme indicators, and serum inflammatory factors were compared between two groups. Results After treatment, the total effective rate of the treatment group was 91.49%, significantly higher than 78.72% in the control group, and the difference was statistically significant between two groups (P < 0.05). After treatment, the VAS scores, duration, and frequency of angina pectoris in two groups decreased (P < 0.05), and the VAS scores, duration, and frequency of angina pectoris in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, Duke and CQQC scores in two groups increased (P < 0.05), and the Duke and CQQC scores in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the serum levels of creatine kinase isoenzyme (CK-MB), creatine kinase (CK), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in two groups of patients were significantly reduced (P < 0.05), and the serum levels of CK-MB, CK, IL-6, and TNF-α in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Yuxintong Capsules combined with Atorvastatin Calcium Tablets has significant therapeutic effects on angina pectoris in coronary heart disease, improving prognosis, enhancing quality of life, and reducing myocardial enzymes and inflammatory factors.

R972

宿迁市中医药科技项目（HD202209）；中西医结合老年病防治省高校重点实验室（扬州大学）开放课题（202544）