急性肾损伤是一种突发性肾功能下降综合征，病理机制多样且治疗难度大。黄芪多糖是从黄芪中提取的主要活性成分，可通过减轻氧化应激反应、减轻炎性损伤、抑制细胞凋亡、抑制肾纤维化、改善线粒体功能、调节肠道菌群、促进维生素D代谢减轻急性肾损伤的严重程度。总结了黄芪多糖防治急性肾损伤的药理作用研究进展，为黄芪多糖治疗急性肾损伤的临床应用提供参考。

Acute kidney injury is a syndrome characterized by sudden renal function decline, with diverse pathological mechanisms and challenging treatment options. Astragalus polysaccharides are the primary active components extracted from Astragali Radix. It can alleviate the severity of acute kidney injury by reducing oxidative stress, mitigating inflammatory damage, inhibiting cell apoptosis, suppressing renal fibrosis, improving mitochondrial function, regulating intestinal microbiota, and promoting vitamin D metabolism. This article summarizes the pharmacological research progress of Astragalus polysaccharides in prevention and treatment of acute kidney injury, providing a reference for its clinical application in treating acute kidney injury.

R285.5;R983

内蒙古自治区自然科学基金项目（2025MS08160）