癫痫是一种以反复发作性脑神经元异常放电为特征的慢性神经系统疾病，当前治疗以抗癫痫药物为主，但存在耐药性、神经毒性、长期复发等问题。槲皮素是一种广泛存在于多种植物中的黄酮类化合物，可通过降低炎症反应、降低氧化应激反应、抑制神经细胞凋亡、调节γ-氨基丁酸系统功能、调节色氨酸代谢、增强神经突出可塑性、纠正兴奋性/抑制性神经递质失衡、调节棘波频率治疗癫痫。总结了槲皮素抗癫痫作用的研究进展，为槲皮素治疗癫痫的临床研究提供参考。

Epilepsy is a chronic neurological disorder characterized by recurrent episodes of abnormal neuronal discharges in the brain. Current treatments primarily involve antiepileptic drugs, but there are problems such as drug resistance, neurotoxicity, and long-term recurrence. Quercetin is a flavonoid compound widely found in various plants, which can treat epilepsy by reducing inflammation, lowering oxidative stress, inhibiting neuronal apoptosis, regulating GABA system function, modulating tryptophan metabolism, enhancing neural plasticity, correcting excitatory/inhibitory neurotransmitter imbalance, and regulating spike frequency. This article summarizes advance of quercetin antiepileptic effects, providing reference for clinical research in treatment of epilepsy with quercetin.

R285.5;R971

海南省高等学校教育教学改革研究项目（Hnjgzc2023-21）