糖尿病肾病是糖尿病最常见的慢性并发症之一，治疗难度较大。白藜芦醇是一种天然多酚类化合物，可通过减轻肾组织氧化损伤、减轻肾组织炎性损伤、抑制肾组织纤维化、阻止肾组织细胞凋亡、抑制病理性血管生成、调节糖脂代谢、调节肠道菌群、改善血管内皮功能治疗糖尿病肾病。总结了白藜芦醇治疗糖尿病肾病的药理作用研究进展，为白藜芦醇对糖尿病肾病临床应用提供参考。

Diabetes nephropathy is one of the most common chronic complications of diabetes, which is difficult to treat. Resveratrol is a natural polyphenolic compound. Resveratrol can treat diabetes nephropathy by reducing renal tissue oxidative damage, reducing renal tissue inflammatory damage, inhibiting renal tissue fibrosis, preventing renal tissue cell apoptosis, inhibiting pathological angiogenesis, regulating glucose and lipid metabolism, regulating intestinal microbiota, and improving vascular endothelial function. This article summarizes the pharmacological effects of resveratrol in treatment of diabetes nephropathy, and provides a reference for the clinical application of resveratrol in treatment of diabetes nephropathy.

R285.5;R983

黑龙江省国医大师学术思想传承科研课题（GY2022-04）