肺癌是全球发病率和死亡率最高的恶性肿瘤之一，严重威胁人类健康。表没食子儿茶素没食子酸酯（EGCG）在茶多酚中的含量最高、活性最强，具有多种药理作用。EGCG可抑制肿瘤细胞增殖、诱导细胞凋亡、抑制细胞迁移和侵袭、调控肺癌表观遗传、抑制肿瘤血管生成、诱导细胞自噬、延缓或逆转肿瘤耐药、调节机体免疫功能。总结了EGCG抗肺癌的作用机制研究进展，以期为肺癌的综合治疗和新药研发提供参考。

Lung cancer is one of the malignant tumors with the highest incidence rate and mortality rate worldwide, posing a serious threat to human health. Epigallocatechin gallate (EGCG), the most abundant and bioactive component in tea polyphenols, exhibits various pharmacological activities. EGCG can inhibit tumor cell proliferation, induce cell apoptosis, suppress cell migration and invasion, regulate lung cancer epigenetics, inhibit tumor angiogenesis, induce autophagy, delay or reverse tumor drug resistance, and modulate immune function. This article summarizes the research progress on the mechanisms of EGCG against lung cancer, aiming to provide references for comprehensive lung cancer treatment and new drug development.

R285.5

国家自然科学基金资助项目（82172760）；中央高水平中医医院临床科研业务费资助（CZ015）