目的 观察关黄母颗粒联合替勃龙片治疗更年期综合征的临床疗效。方法 选取2024年1～8月天津市北辰区中医医院收治的63例更年期综合征患者，所有患者采用随机数字表法分为对照组（31例）和治疗组（32例）。对照组口服替勃龙片，2.5 mg/次，1次/d。治疗组在对照组基础上温开水冲服关黄母颗粒，1袋/次，3次/d。两组患者连续治疗3个月。对比两组临床疗效、临床症状、生活质量、焦虑抑郁情况、血清性激素水平。结果 治疗组的好转率为93.75%，高于对照组的好转率74.19%（P＜0.05）。两组治疗后改良Kupperman评分、更年期评定量表（MRS）评分、焦虑自评量表（SAS）评分、抑郁自评量表（SDS）评分均显著下降（P＜0.05），且治疗组的改良Kupperman评分、MRS评分、SAS评分、SDS评分低于对照组（P＜0.05）。两组治疗后血清黄体生成素（LH）、促卵泡生成素（FSH）水平显著下降，血清雌二醇（E₂）水平显著升高（P＜0.05），且治疗组的血清LH、FSH水平显著低于对照组，血清E₂水平显著高于对照组（P＜0.05）。结论 关黄母颗粒联合替勃龙片治疗更年期综合征具有较好的临床疗效，可减轻临床症状，改善患者的性激素水平。

Objective To observe the clinical efficacy of Guanhuangmu Granules combine with Tibolone Tablets in treatment of menopausal syndrome. Methods 63 Patients with menopausal syndrome admitted to Tianjin Beichen Traditional Chinese Medicine Hospital from January to August 2024 were selected. All patients were divided into control group (31 cases) and treatment group (32 cases) by using a random number table method. The control group took orally Tibolone Tablets at a dose of 2.5 mg/time, once daily. The treatment group took Guanhuangmu Granules with warm water on the basis of the control group, 1 bag/time, 3 times daily. Two groups of patients were treated continuously for 3 months. The clinical efficacy, clinical symptoms, quality of life, anxiety and depression status, and serum sex hormones levels were compared between two groups. Results The improvement rate of the treatment group was 93.75%, which was higher than the improvement rate of 74.19% in the control group (P < 0.05). After treatment, the modified Kuperman score, menopausal rating scale (MRS) score, self-rating anxiety scale (SAS) score, and self-rating depression scale (SDS) score in two groups significantly decreased (P < 0.05), and the modified Kuperman score, MRS score, SAS score, and SDS score in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) significantly decreased in two groups, but the serum level of estradiol (E₂) significantly increased (P < 0.05). The serum levels of LH and FSH in the treatment group were significantly lower than those in the control group, but the serum level of E₂ was significantly higher than that in the control group (P < 0.05). Conclusion The combination of Guanhuangmu Granules and Tibolone Tablets has good clinical efficacy in treatment of menopausal syndrome, which can alleviate clinical symptoms and improve patients’ sex hormone levels.

R984

吴阶平医学基金会临床科研专项（320.6750.2023-16-3）