目的 探寻金鸡胶囊联合人干扰素α2b治疗慢性宫颈炎的临床疗效。方法 选取秦皇岛市妇幼保健院2024年1月—12月收治的100例慢性宫颈炎患者，经随机数字表法分成对照组和治疗组，各50例。对照组给予人干扰素α2b凝胶，每隔1天使用1次，1 g/次。治疗组在对照组基础上联合金鸡胶囊，4粒/次，3次/d。两组连续治疗14 d。观察两组治疗效果和临床症状缓解情况，比较两组血清肿瘤坏死因子-α（TNF-α）、单核细胞趋化蛋白-1（MCP-1）、白细胞介素-10（IL-10）、白细胞介素-1β（IL-1β）水平。结果 治疗后，治疗组总有效率（98.00%）较对照组（82.00%）显著提高（P＜0.05）。治疗组下腹部坠痛缓解时间、乏力症状减轻时间、白带恢复正常时间均较对照组短（P＜0.05）。治疗后两组TNF-α、MCP-1、IL-1β降低，IL-10升高（P＜0.05）；治疗后，治疗组TNF-α、MCP-1、IL-1β低于对照组，IL-10高于对照组（P＜0.05）。结论 金鸡胶囊联合人干扰素α2b凝胶治疗慢性宫颈炎患者可显著提高疗效，缩短白带异常、下腹坠痛等临床症状缓解时间，调节炎症因子水平，且不会过度增加患者不适感，该联合方案可作为慢性宫颈炎优化治疗方案在临床推广应用。

Objective To explore the effect of Jinji Capsules combined with human interferon α2b in treatment of chronic cervicitis. Methods A total of 100 patients with chronic cervicitis who were admitted to Qinhuangdao Maternal and Child Health Hospital from January 2024 to December were selected. They were randomly divided into control group and treatment group, with 50 cases in each group. Patients in control group were given Human Interferon α2b Gel, once every other day, 1 g each time. Patients in treatment group was treated with the same gel in combination with Jinji Capsules, 4 capsules each time, 3 times daily. Both groups received continuous treatment for 14 d. The therapeutic effects and clinical symptom relief of two groups were observed, and the levels of serum TNF-α, MCP-1, IL-10, and IL-1β of two groups were compared. Results After treatment, the total effective rate of the treatment group (98.00%) was significantly higher than that of the control group (82.00%) (P < 0.05). The time for relief of lower abdominal distension pain, the time for alleviation of fatigue symptoms, and the time for recovery of normal vaginal discharge in the treatment group were all shorter than those in control group (P < 0.05). After treatment, the levels of TNF-α, MCP-1, and IL-1β decreased and the level of IL-10 increased in both groups (P < 0.05). After treatment, the levels of TNF-α, MCP-1, and IL-1β in treatment group were lower than those in control group, but the level of IL-10 was higher than that in control group (P < 0.05). Conclusion The combination of Jinji Capsules and Human Interferon α2b Gel in treatment of patients with chronic cervicitis can significantly improve the therapeutic effect, shorten the recovery time of clinical symptoms such as abnormal vaginal discharge and lower abdominal distension, regulate the levels of inflammatory factors, and will not excessively increase the discomfort of patients. This combined treatment plan can be used as an optimized treatment plan for chronic cervicitis and be widely promoted and applied in clinical practice.

R984

秦皇岛市市级科学技术研究与发展计划项目（202501A047）