目的 探讨喉咽清口服液联合头孢曲松治疗急性化脓性扁桃体炎的临床疗效。方法 选取2024年3月—2025年4月青岛市第八人民医院收治的102例急性化脓性扁桃体炎患儿，按照随机数字法分为对照组和治疗组，每组51例。对照组患者静脉滴注注射用头孢曲松钠，70 mg/kg，加入0.9%氯化钠250 mL中稀释后滴注，1次/d。治疗组在对照组的基础上口服喉咽清口服液，10～20 mL/次，3次/d。两组用药7 d。观察两组临床疗效，比较两组症状消退时间、白细胞介素-1β（IL-1β）、超敏C反应蛋白（hs-CRP）、血清降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，治疗组总有效率（96.08%）高于对照组（84.31%）（P＜0.05）。治疗后，与对照组对比，治疗组咽部疼痛消退时间、疲乏无力消退时间、发热完全消退时间、脓性分泌物消退时间均较短（P＜0.05）；治疗后，两组IL-1β、hs-CRP、TNF-α、PCT水平低于治疗前（P＜0.05）；且与对照组对比，治疗组IL-1β、hs-CRP、TNF-α、PCT水平均较低（P＜0.05）。结论 喉咽清口服液联合头孢曲松钠治疗急性化脓性扁桃体炎效果显著，能降低局部炎症反应，并有效改善咽部黏膜状态，值得借鉴与应用。

Objective To explore the clinical effect of Houyanqing Oral Liquid combined with ceftriaxone in treatment of acute suppurative tonsillitis. Methods From March 2024 to April 2025, 102 children with acute suppurative tonsillitis who were admitted to Qingdao Eighth People’s Hospital were selected and divided into control group and treatment group according to the random number method, with 51 cases in each group. Children in control group were iv administered with Ceftriaxone Sodium for injection at a dose of 70 mg/kg, diluted in 250 mL of 0.9% sodium chloride solution and then infused. The infusion was performed once daily. Children in treatment group were po administered with Houyanqing Oral Liquid in addition to the control group, at a dose of 10 to 20 mL per time, three times daily. Both groups were treated for 7 d. The clinical efficacy of two groups were observed, and symptom disappearance time, serum IL-1β, hs-CRP, PCT, and TNF-α levels of two groups were compared. Results After treatment, the total effective rate of the treatment group (96.08%) was higher than that of the control group (84.31%) (P < 0.05). After treatment, compared with control group, pharyngeal pain disappearance time, tired and weak disappearance time, fever disappearance time, purulent discharge disappearance time in treatment group were shorter (P < 0.05). After treatment, the levels of IL-1β, hs-CRP, TNF-α, and PCT in both groups were lower than those before treatment (P < 0.05). And compared with control group, the levels of IL-1β, hs-CRP, TNF-α, and PCT in treatment group were all lower (P < 0.05). Conclusion The combination of Huoyanqing Oral Liquid and ceftriaxone sodium in treatment of acute suppurative tonsillitis has a remarkable effect. It can reduce local inflammatory reactions and effectively improve the condition of the pharyngeal mucosa, which is worthy of reference and application.

R985

山东省医药卫生科技发展计划项目（202007020149）