目的 观察芩翘口服液联合人干扰素α2b喷雾剂治疗儿童疱疹性咽峡炎临床疗效。方法 回顾性选取2023年3月—2025年4月武汉市中医医院门诊收治的98例疱疹性咽峡炎患儿，按照用药方案的不同分为对照组（49例）和治疗组（49例）。对照组患儿咽峡喷用人干扰素α2b喷雾剂，1～2喷/次，3次/d。在对照组的基础上，治疗组口服芩翘口服液，20 mL/次，3次/d。两组患儿均治疗7 d。观察两组患儿临床疗效，比较治疗前后两组患儿中医症状积分、匹兹堡睡眠质量指数量表（PSQI）评分和世界卫生组织生活质量量表（WHOQOL-BREF）评分，及血清白细胞介素-6（IL-6）、C反应蛋白（CRP）、降钙素原（PCT）和肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，治疗组总有效率为95.92%，明显高于对照组的总有效率81.63%（P＜0.05）。治疗后，与对照组对比，治疗组发热、咽部疼痛、咽部疱疹等症状积分均显著低于对照组（P＜0.05）。治疗后，两组患儿PSQI评分比治疗前明显降低，而WHOQOL-BREF评分明显升高（P＜0.05）；且治疗后，治疗组评分明显好于对照组（P＜0.05）。治疗后，两组患儿IL-6、CRP、PCT水平比治疗前显著下降（P＜0.05），且治疗组血清因子水平比对照组降低更显著（P＜0.05）。结论 芩翘口服液与人干扰素α2b喷雾剂协同治疗疗效显著，加快消退症状，促使咽部炎症降低，患儿睡眠及生活质量提高。

Objective To observe the clinical efficacy of Qinqiao Oral Liquid combined with combined with Human Interferon α2b Spray in treatment of herpetic angina in children. Methods The clinical data of children (98 cases) with herpetic angina in Wuhan Traditional Chinese Medicine Hospital from March 2023 to April 2025 were analyzed retrospectively, and they were divided into control (49 cases) and treatment (49 cases) group based on different treatments. Children in the control group were administered with Human Interferon α2b Spray, 1 — 2 press/time, three times daily. Children in the treatment group were po administered with Qinqiao Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, and the TCM symptom scores, PSQI and WHOQOL-BREF scores, and the levels of serum IL-6, CRP, PCT and TNF-α in two groups before and after treatment were compared. Results After treatment, the effective rate in the treatment group was 95.92%, which was significantly higher than that in the control group (81.63%, P < 0.05). After treatment, compared with the control group, the scores of symptoms such as fever, pharyngeal pain, and pharyngeal herpes in treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the PSQI score of children in two groups was significantly lower than before treatment, while the WHOQOL-BREF score was significantly higher (P < 0.05), and the score of the treatment group was significantly better than that of the control group (P < 0.05). After treatment, the levels of IL-6, CRP, and PCT in two groups were significantly decreased compared with before treatment (P < 0.05), and the serum factor levels in the treatment group were decreased more significantly than those in the control group (P < 0.05). Conclusion The combination therapy of Human Interferon α2b Spray and Qinqiao Oral Liquid demonstrates significant efficacy, accelerating symptom resolution, reducing pharyngeal inflammation, improving sleep quality and quality of life in children.

R985

湖北省卫生健康委员会中医药科研项目（ZY2021Z008）