目的 探讨荜铃胃痛颗粒联合奥美拉唑肠溶片治疗胃食管反流病的临床疗效。方法 选取2023年4—2025年6月在秦皇岛市第二医院就诊的胃食管反流病共计186例，将所有患者按照随机数字表法分为对照组和治疗组，每组各93例。对照组早晚口服奥美拉唑肠溶片，1片/次，2次/d。治疗组在对照组基础上口服荜铃胃痛颗粒，1袋/次，3次/d。两组患者总共持续服用8周。比较两组的治疗效果、反流参数、症状体征、生活质量、血清指标。结果 对照组的总有效率为87.10%，治疗组的总有效率为95.70%，两组组间比较差异显著（P＜0.05）。两组治疗后的反流次数、最长反流持续时间、pH值＜4的总时长比例均显著降低（P＜0.05），且治疗组治疗后的反流次数、最长反流持续时间、pH值＜4的总时长比例均显著低于对照组（P＜0.05）。两组治疗后的反流体征评分（RFS）和反流症状指数（RSI）评分均明显降低，胃食管反流病生存质量量表（GQOL）评分明显升高（P＜0.05）；治疗组治疗后RFS、RSI评分明显低于治疗组，GQOL评分明显高于治疗组（P＜0.05）。两组治疗后的血清白细胞介素-8（IL-8）水平明显降低，血清前列腺素E₂（PGE₂）、一氧化氮（NO）水平明显升高（P＜0.05）；治疗组治疗后的血清IL-8水平明显低于对照组，血清PGE₂、NO水平明显高于对照组（P＜0.05）。结论 荜铃胃痛颗粒联合奥美拉唑肠溶片可提高胃食管反流病的疗效，减轻反流症状体征和炎症反应，有助于促进黏膜功能恢复，提高生活质量。

Objective To investigate the clinical efficacy of Biling Weitong Granules combined with Omeprazole Enteric-coated Tablets in treatment of gastroesophageal reflux disease. Methods A total of 186 patients with gastroesophageal reflux disease who were treated at The Second Hospital of Qinhuangdao from April 2023 to June 2025 were selected. All patients were divided into control group and treatment group according to the random number table method, with 93 cases in each group. The control group received oral Omeprazole Enteric-coated Tablets, 1 tablets/time, twice daily. The treatment group additionally took Biling Weitong Granules on the base of control group, 1 bag/time, three times daily. Two groups of patients received continuous treatment for a total of 8 weeks. The therapeutic efficacy, reflux parameters, symptoms and signs, quality of life, and serum indicators were compared between two groups. Results The total effective rate of the control group was 87.10%, while the total effective rate of the treatment group was 95.70%, and the difference between two groups was significant (P < 0.05). The number of reflux events, longest reflux duration, and total duration of pH < 4 in two groups after treatment were significantly reduced (P < 0.05), and the treatment group had significantly lower reflux events, longest reflux duration, and total duration of pH < 4 compared to the control group (P < 0.05). The reflux sign score (RFS) and reflux symptom index (RSI) scores were significantly reduced in two groups after treatment, but the quality of life scale (GQOL) score for gastroesophageal reflux disease was significantly increased (P < 0.05). After treatment, the RFS and RSI scores of the treatment group were significantly lower than those of the treatment group, but the GQOL score was significantly higher than that of the treatment group (P < 0.05). The serum levels of interleukin-8 (IL-8) were significantly reduced, but the serum levels of prostaglandin E₂ (PGE₂) and nitric oxide (NO) were significantly increased after treatment in two groups (P < 0.05). The serum levels of IL-8 in the treatment group were significantly lower than those in the control group after treatment, while the serum levels of PGE₂ and NO were significantly higher than those in the control group (P < 0.05). Conclusion The combination of Biling Weitong Granules and Omeprazole Enteric-coated Tablets can improve the efficacy of gastroesophageal reflux disease, alleviate reflux symptoms, signs, and inflammatory reactions, help promote mucosal function recovery, and improve quality of life.

R975

河北省卫生健康委科研基金项目（20231894）