阿尔茨海默病的发病机制复杂，与多种因素有关。二苯乙烯苷是何首乌中主要活性成分，可通过抑制β淀粉样蛋白生成和沉积、抑制α-突触核蛋白聚集、减少Tau蛋白磷酸化、减轻炎症反应、抑制神经元凋亡、增强抗氧化能力、增强神经突触可塑性治疗阿尔茨海默病。总结了二苯乙烯苷治疗阿尔茨海默病的药理作用研究进展，为二苯乙烯苷的临床应用提供循证支持。

The pathogenesis of Alzheimer's disease is complex and related to multiple factors. Stilbene glycoside is the main active ingredient in Polygoni Multiflori Radix. Stilbene glycoside can treat Alzheimer's disease by inhibiting the generation and deposition of β-amyloid protein, inhibiting the aggregation of α-synuclein, reducing Tau protein phosphorylation, alleviating inflammatory response, inhibiting neuronal apoptosis, enhancing antioxidant capacity, and enhancing synaptic plasticity. This article summarizes the pharmacological research progress of stilbene glycoside in treatment of Alzheimer's disease, providing evidence-based support for the clinical application of stilbene glycoside.

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北京市医院管理中心重点医学专业发展计划建设项目（ZYLX202132）