肝癌是全球第5大癌症致死病因，发病率和死亡率居高不下。黄芪甲苷是黄芪中的关键活性成分，具有广泛的药理活性。黄芪甲苷通过抑制细胞增殖、诱导细胞凋亡、抑制细胞侵袭和迁移、调控能量代谢重编程、逆转肿瘤多药耐药、调节机体免疫系统防治肝癌。总结了黄芪甲苷抗肝癌的药理作用研究进展，以期为黄芪甲苷在肝癌精准治疗中的临床转化提供依据，并为抗肿瘤新药研发提供思路。

Hepatocellular carcinoma is the fifth leading cause of cancer death in the world, with high incidence rate and mortality. Astragaloside IV is a key active ingredient in Astragali Radix, with a wide range of pharmacological activities. Astragaloside IV inhibits cell proliferation, induces cell apoptosis, suppresses cell invasion and migration, regulates energy metabolism reprogramming, reverses tumor multidrug resistance, and regulates the body's immune system to prevent and treat hepatocellular carcinoma. This article summarizes the research progress on the pharmacological effects of astragaloside IV against hepatocellular carcinoma, in order to provide a basis for the clinical translation of astragaloside IV in precision treatment on hepatocellular carcinoma and to provide ideas for the development of new anti-tumor drugs.

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黑龙江省自然科学基金计划项目（LH2023H072，PL2024H244）