目的 观察乌鸡白凤软胶囊联合黄体酮软胶囊和戊酸雌二醇片治疗肾虚型月经过少的临床效果。方法 选取2023年1月—2023年12月在延安市中医医院妇科就医的150例肾虚型月经过少女性患者，采用随机分组方式将患者分为对照组和治疗组，每组各75例。对照组自月经周期第5天开始口服戊酸雌二醇片，1 mg/次，1次/d，连续用药21 d。在戊酸雌二醇片服用至第12天时加用黄体酮胶囊，100 mg/次，2次/d，连续服用10 d。治疗组在对照组用药基础上口服乌鸡白凤软胶囊，1.8 g/次，3次/d。1个月经周期为1个疗程，两组患者共治疗3个疗程。比较两组的临床疗效、中医证候积分、月经失血图（PBAC）评分、子宫内膜厚度、血清性激素水平。结果 治疗组的总有效率为90.67%，高于对照组的总有效率78.67%，组间比较差异有统计学意义（P＜0.05）。治疗后，两组的中医证候评分均下降（P＜0.05），并且治疗组的中医证候评分低于对照组（P＜0.05）。治疗后，两组的PBAC评分均上升（P＜0.05），治疗组的PBAC评分明显高于对照组（P＜0.05）。治疗后，两组的子宫内膜厚度均增加（P＜0.05），治疗组的子宫内膜厚度大于对照组（P＜0.05）。治疗后，两组血清中的卵泡刺激素（FSH）、促黄体生成素（LH）、雌二醇（E₂）水平均升高（P＜0.05），治疗组患者的血清FSH、LH、E2水平高于对照组（P＜0.05）。结论 乌鸡白凤软胶囊联合黄体酮软胶囊和戊酸雌二醇片治疗肾虚型月经过少的疗效显著，可改善临床症状，提高血清性激素水平。

Objective To observe the therapeutic effect of Wuji Baifeng Soft Capsules combined with Progesterone Capsules and Estradiol Valerate Tablets in treatment of renal deficiency type hypomenorrhea. Methods 150 Female patients with kidney deficiency type hypomenorrhea who received medical treatment in the Department of Gynecology, Yan’an Hospital of TCM from January 2023 to December 2023 were divided into control group and treatment group according to random grouping method, with 75 patients in each group. The control group were po administered with Estradiol Valerate Tablets from the 5th day of the menstrual cycle, at a dose of 1 mg/time, once daily, for 21 consecutive days. On the 12th day, the treatment group was po administered with Progesterone Capsules 100 mg/time, twice daily, for 10 consecutive days. The treatment group took Wuji Baifeng Soft Capsules orally on the basis of the control group's medication at a dose of 1.8 g/time, three times daily. One menstrual cycle was one course of treatment, and two groups of patients were treated for a total of three courses. The clinical efficacy, TCM syndrome score, PBAC score, endometrial thickness, and serum sex hormones levels were compared between two groups. Results The total effective rate of the treatment group was 90.67%, which was higher than the total effective rate of 78.67% in the control group, and the difference was statistically significant between the groups (P < 0.05). After treatment, the TCM symptom scores of two groups decreased (P < 0.05), and the TCM symptom scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, the PBAC scores of two groups increased (P < 0.05), and the PBAC score of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the endometrial thickness in two groups increased (P < 0.05), and thicker endometrium in the treatment group was bigger than that of the control group (P < 0.05). After treatment, the serum levels of FSH, LH, and E₂ of two groups increased (P < 0.05), and the serum levels of FSH, LH, and E₂ in the treatment group was higher than that in the control group (P < 0.05). Conclusion Wuji Baifeng Soft Capsules combined with Progesterone Capsules and Estradiol Valerate Tablets has a significant therapeutic effect in treatment of renal deficiency type hypomenorrhea,, which can improve clinical symptoms and increase serum sex hormone levels.

R984

陕西省中医药管理局科研课题（2021-GJ-LC015）