目的 探讨慢性盆腔炎采用妇炎康丸与克林霉素联合治疗的临床疗效。方法 纳入2023年6月—2024年6月在三二〇一医院就诊的120例慢性盆腔炎患者，按随机数字表法分为对照组（n=60）和治疗组（n=60）。对照组患者口服克林霉素磷酸酯片，0.3 g/次，3次/d。治疗组患者口服妇炎康丸，5 g/次，2次/d。两组均以4周为1个疗程，连续治疗3个疗程。对比并分析两组患者临床治疗效果、盆腔炎性包块直径、盆腔积液深度、血清炎症因子、临床症状消失时间。结果 治疗后，治疗组总有效率明显高于对照组（93.33% vs 80.00%，P＜0.05）。治疗后，两组盆腔炎性包块直径和盆腔积液深度均明显小于治疗前（P＜0.05），且治疗组患者盆腔炎性包块直径和盆腔积液深度明显小于对照组（P＜0.05）。治疗后，两组血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）水平均低于治疗前（P＜0.05），且治疗组患者血清IL-6、TNF-α、CRP水平明显低于对照组（P＜0.05）。治疗后，治疗组下腹部疼痛消失时间、坠胀消失时间、腰骶部酸痛消失时间以及白带增多消失时间均短于对照组（P＜0.05）。结论 妇炎康丸联合克林霉素治疗慢性盆腔炎能够提升临床疗效，减小盆腔炎性包块直径和盆腔积液深度，降低血清炎症因子水平。

Objective To explore the clinical efficacy of the combined treatment of Fuyankang Pills and clindamycin for chronic pelvic inflammatory disease. Methods A total of 120 patients with chronic pelvic inflammatory disease who visited 3201 Hospital from June 2023 to June 2024 were included and divided into the control group (n=60) and the treatment group (n=60) according to the random number table method. Patients in control group were po administered with Clindamycin Phosphate Tablets, 0.3 g each time, three times daily. Patients in treatment group took Fuyankang Pills orally, 5 g each time, twice daily. Both groups were treated with 4 weeks as one course of treatment for 3 consecutive courses. Both groups of patients took 4 weeks as one course of treatment and continued the treatment for 3 courses. The clinical therapeutic effects, diameters of pelvic inflammatory masses, depth of pelvic effusion, serum inflammatory factors, and disappearance time of clinical symptoms of the two groups of patients were compared and analyzed. Results After treatment, the total effective rate of the treatment group was significantly higher than that of the control group (93.33% vs 80.00%, P < 0.05). After treatment, the diameters of pelvic inflammatory masses and the depth of pelvic effusion in both groups were significantly smaller than those before treatment (P < 0.05), and diameters of pelvic inflammatory masses and the depth of pelvic effusion in the treatment group were significantly smaller than those in the control group (P < 0.05). After treatment, the levels of serum IL-6, TNF-α, and CRP in both groups were lower than those before treatment (P < 0.05), and the levels of serum factors in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the relief time for lower abdominal pain, distension, lumbosacral soreness and increased vaginal discharge in the treatment group was shorter than that in the control group (P < 0.05). Conclusion The combined treatment of Fuyankang Pills and clindamycin for chronic pelvic inflammatory disease can improve the curative effect, reduce the diameter of pelvic inflammatory masses and the depth of pelvic effusion, lower the levels of serum inflammatory factors.

R984

陕西省卫生健康科研基金资助项目（2024D025）