目的 探讨红金消结片联合米非司酮片治疗卵巢囊肿的临床疗效。方法 将2023年9月—2024年11月在上海市嘉定区南翔医院就诊的女性卵巢囊肿患者共计102例纳入研究，按随机数字表法将所有患者分为对照组和治疗组，每组51例。对照组口服米非司酮片，1片/次，1次/d。治疗组在对照组基础上口服红金消结片，4片/次，3次/d。两组连续治疗3个月。比较两组患者的治疗疗效、痛经症状、囊肿最大截面积、血清指标。结果 治疗组治愈率（80.39%）明显高于对照组（62.75%），组间比较差异显著（P＜0.05）。两组治疗后的痛经严重程度评分、发作时间评分均显著减小（P＜0.05）；治疗组治疗后的痛经严重程度评分、发作时间评分低于对照组（P＜0.05）。两组治疗后的囊肿最大截面积明显缩小（P＜0.05），治疗组治疗后囊肿最大截面积小于对照组（P＜0.05）。两组治疗后的血清热休克蛋白70（HSP-70）、肿瘤坏死因子-α（TNF-α）、糖类抗原125（CA125）水平显著降低（P＜0.05），且治疗组治疗后血清HSP-70、TNF-α、CA125水平低于对照组（P＜0.05）。两组治疗后的血清抗缪勒管激素（AMH）、卵泡刺激素（FSH）、促黄体生成素（LH）水平均低于治疗前（P＜0.05），且治疗组治疗后血清AMH、FSH、LH水平低于对照组（P＜0.05）。结论 红金消结片联合米非司酮片可提高卵巢囊肿的临床疗效，降低痛经程度和囊肿最大截面积，减轻炎症反应，调节性激素水平。

Objective To investigate the clinical efficacy of Hongjin Xiaojie Tablets combined with Mifepristone Tablets in treatment of ovarian cysts. Methods A total of 102 female ovarian cyst patients who visited Shanghai Jiading Nanxiang Hospital from September 2023 to November 2024 were included in the study. All patients were divided into control group and treatment group using a random number table method, with 51 patients in each group. The control group took Mifepristone Tablets orally, 1 tablets/time, once daily. The treatment group took Hongjin Xiaojie Tablets orally on the basis of the control group, 4 tablets/time, 3 times daily. Both groups were treated continuously for 3 months. The treatment efficacy, dysmenorrhea symptoms, maximum cross-sectional area of cysts, and serum indicators were compared between two groups of patients. Results The cure rate of the treatment group (80.39%) was significantly higher than that of the control group (62.75%), and the difference was significant between the groups (P < 0.05). The severity score and onset time score of dysmenorrhea significantly decreased in two groups after treatment (P < 0.05), the severity score and onset time score of dysmenorrhea in the treatment group were lower than those in the control group after treatment (P < 0.05). After treatment, the maximum cross-sectional area of the cysts in two groups significantly decreased (P < 0.05), and the maximum cross-sectional area of the cysts in the treatment group was smaller than that in the control group (P < 0.05). After treatment, the serum levels of HSP-70, TNF-α, and CA125 in two groups were significantly reduced (P < 0.05), and the serum levels of HSP-70, TNF-α, and CA125 in the treatment group were lower than those in the control group (P < 0.05). The serum levels of AMH, FSH, and LH in two groups were significantly reduced after treatment (P < 0.05), and the serum levels of AMH, FSH, and LH in the treatment group were lower than those in the control group after treatment (P < 0.05). Conclusion The combination of Hongjin Xiaojie Tablets and Mifepristone Tablets can improve the clinical efficacy of ovarian cysts, reduce the degree of dysmenorrhea and the maximum cross-sectional area of cysts, alleviate inflammatory reactions, and regulate hormone levels.

R984

上海市嘉定区卫生健康委员会科研课题（2021-KY-06）