目的 探讨芪蛭降糖胶囊联合盐酸吡格列酮片治疗2型糖尿病的临床疗效。方法 选取2023年3月—2025年3月在重庆医科大学附属永川医院就诊的2型糖尿病患者，共计132例，患者按照随机数字表法分为对照组和治疗组，每组各66例。对照组口服盐酸吡格列酮片，30 mg/次，1次/d。治疗组在对照组基础上口服芪蛭降糖胶囊，2.5 g/次，3次/d。两组持续治疗3个月。比较两组的临床疗效、生活质量、症状改善时间、实验指标。结果 对照组的总有效率为81.82%，治疗组的总有效率为93.94%，组间总有效率差异显著（P＜0.05）。治疗后，两组的糖尿病生活质量量表（DSQL）评分显著降低（P<0.05），且治疗组DSQL评分低于对照组（P＜0.05）。治疗组患者多尿、多饮、乏力改善时间均短于对照组（P＜0.05）。两组治疗后的空腹血糖（FBG）、糖化血红蛋白（HbA1c）、平均血糖波动幅度（MAGE）、平均血糖标准差（SDBG）、胰岛素抵抗指数（HOMA-IR）和血清白细胞介素-8（IL-8）、骨钙素（BGP）、C反应蛋白（CRP）水平均显著降低，胰岛素敏感性（HOMA-IS）、胰岛β细胞功能指数（HOMA-β）显著升高（P＜0.05）；治疗组治疗后的MAGE、SDBG、HOMA-IR和血清IL-8、BGP、CRP水平低于对照组，HOMA-IS、HOMA-β高于对照组（P＜0.05）。结论 芪蛭降糖胶囊联合盐酸吡格列酮片可提高2型糖尿病的临床疗效，提高生活质量，减轻血糖波动，改善胰岛β细胞功能，减轻炎症反应。

Objective To investigate the clinical efficacy of Qizhi Jiangtang Capsules combined with Pioglitazone Hydrochloride Tablets in treatment of type 2 diabetes mellitus. Methods A total of 132 patients with type 2 diabetes mellitus who visited Yongchuan Hospital Affiliated to Chongqing Medical University from March 2023 to March 2025 were selected. Patients were divided into control group and treatment group according to the random number table, with 66 cases in each group. The control group took Pioglitazone Hydrochloride Tablets orally at a dose of 30 mg/time, once daily. The treatment group took Qizhi Jiangtang Capsules orally in addition to the control group at a dose of 2.5 g/time, three times daily. Two groups were treated continuously for three months. The clinical efficacy, quality of life, symptom improvement time, and experimental indicators were compared between two groups. Results The total effective rate of the control group was 81.82%, while the total effective rate of the treatment group was 93.94%, and the difference was significant between the groups (P < 0.05). After treatment, the DSQL scores in the two groups were significantly reduced (P < 0.05), and the DSQL scores in the treatment group were lower than those in the control group (P < 0.05). The improvement time of polyuria, polydipsia, and fatigue in the treatment group was shorter than that in the control group (P < 0.05). After treatment, FBG, HbA1c, MAGE, SDBG, HOMA-IR, and serum IL-8, BGP, and CRP levels were significantly reduced in two groups, but HOMA-IS and HOMA-β were decreased (P < 0.05). MAGE, SDBG, HOMA-IR, serum IL-8, BGP, and CRP in the treatment group were lower than those in the control group after treatment, while HOMA-IS and HOMA-β were higher than those in the control group (P < 0.05). Conclusion Qizhi Jiangtang Capsules combined with Pioglitazone Hydrochloride Tablets can improve the clinical efficacy of type 2 diabetes mellitus, improve the quality of life, reduce blood sugar fluctuations, improve the function of pancreatic islet β cells, and reduce inflammatory reaction.

R978

重庆市科卫联合中医药技术创新与应用发展项目（YJLC202126）