目的 观察金银花口服液联合氨溴特罗口服溶液治疗小儿支气管肺炎的临床疗效。方法 选取2022年1月—2024年12月十堰市太和医院收治的150例小儿支气管肺炎患儿，利用组间匹配原则将患者分为对照组75例和治疗组75例。对照组给予盐酸氨溴特罗口服液，≤1岁，5 mL/次；1岁＜患儿年龄≤3岁，7.5 mL/次；3岁＜患儿年龄≤5岁，10 mL/次；＞5岁：15 mL/次，均2次/d。治疗组在对照组治疗方案基础上口服金银花口服液，≤3岁，10 mL/次，2次/d；3岁＜患儿年龄≤7岁，10 mL/次，3次/d。两组均连续治疗12 d。观察两组的临床疗效和临床症状消失时间，比较治疗前后血清炎性因子和白细胞（WBC）水平。结果 治疗后，治疗组总有效率是97.33%，显著高于对照组的86.67%（P＜0.05）。与对照组相比，治疗组咳嗽及啰音消失、体温及胸片恢复正常时间均显著较短（P＜0.05）。治疗后，两组C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、淀粉样蛋白（SAA）、WBC均较治疗前下降（P＜0.05），且治疗组CRP、IL-6、TNF-α、SAA、WBC低于对照组（P＜0.05）。结论 金银花口服液联合氨溴特罗口服溶液治疗小儿支气管肺炎利于提高患儿治疗效果，缩短临床症状改善时间，改善机体炎症状态。

Objective To observe the effects of Jinyinhua Oral Liquid combined with ambroxol in treatment of bronchopneumonia in children. Methods A total of 150 children with bronchopneumonia admitted to Taihe Hospital in Shiyan City from January 2022 to December 2024 were selected. The patients were divided into a control group of 75 cases and a treatment group of 75 cases by using the principle of matching between groups. Children in control group were given Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution, for children ≤1 year old, 5 mL each time. For children aged 1 year to 3 years, 7.5 mL each time, for children aged 3 to 5 years old, 10 mL each time, for children over 5 years old, 15 mL each time, twice daily. Children in treatment group orally took Jinyinhua Oral Liquid on basis of treatment plan of control group. For children ≤ 3 years old, 10 mL each time, twice daily, for children aged 3 to 7 years old, 10 mL each time, 3 times daily. Both groups were treated continuously for 12 d. The clinical efficacy and the disappearance time of clinical symptoms of two groups were observed, and the levels of serum inflammatory factors and white blood cells (WBC) in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 97.33%, significantly higher than 86.67% of the control group (P < 0.05). Compared with control group, the time for cough and rales to disappear, body temperature and chest X-ray to return to normal in treatment group was significantly shorter (P < 0.05). After treatment, CRP, IL-6, TNF-α, SAA, and WBC in both groups decreased compared with those before treatment (P < 0.05), and CRP, IL-6, TNF-α, SAA, and WBC in treatment group were lower than those in control group (P < 0.05). Conclusion Jinyinhua Oral Liquid combined with ambroxol in treatment of bronchopneumonia in children can improve the therapeutic effect of children, shorten the time for improvement of clinical symptoms, and improve the inflammatory state of body.

R974;R985

湖北省重点研发计划项目（2022SF-235）