目的 探讨牛黄宁宫片联合布南色林治疗精神分裂症的临床疗效。方法 选取2022年3月—2024年12月在河北省第六人民医院治疗的精神分裂症患者120例，随机分为对照组和治疗组，每组各60例。对照组口服布南色林片，起始剂量4 mg/次，2次/d，2周内根据患者病情及耐受情况，逐渐增至8～16 mg/d。在对照组的基础上，治疗组口服牛黄宁宫片，5片/次，3次/d。两组患者治疗8周。观察两组患者临床疗效，比较治疗前后两组患者阳性和阴性综合征量表（PANSS）、临床总体印象量表–病情严重程度（CGI-SI）、个体和社会功能量表（PSP）、健康状况调查问卷（SF-36）评分和副反应量表（TESS）评分，及不良反应发生情况。结果 治疗后，治疗组总有效率为95.00%，明显高于对照组总有效率（83.33%，P＜0.05）。治疗后，两组PANSS和CGI-SI评分均低于组内治疗前，而PSP、SF-36评分高于组内治疗前（P＜0.05），且治疗组PANSS、CGI-SI、PSP、SF-36评分明显好于同期对照组（P＜0.05）。治疗后，治疗组TESS评分显著低于对照组（P＜0.05），治疗组静坐不能、失眠、便秘的发生率显著低于对照组（P＜0.05）。结论 针对精神分裂症采用牛黄宁宫片联合布南色林治疗，可获得较满意的疗效，不仅能减轻患者的精神症状和病情严重程度，还可改善社会功能和生活质量，且不良反应更轻。

Objective To investigate the clinical efficacy of Niuhuang Ninggong Tablets combined with blonanserin in treatment of schizophrenia. Methods Patients (120 cases) with schizophrenia in the Sixth People’s Hospital of Hebei Province from March 2022 to December 2024 were randomly divided into control and treatment group, and each had 60 cases. Patient in the control group were po administered with Blonanserin Tablets, the starting dose was 4 mg/time, twice daily, and gradually increased to 8 — 16 mg/d within 2 weeks according to the patient's condition and tolerance. Patient in the treatment group were po administered with Niuhuang Ninggong Tablets on the basis of the control group, 5 tablets/time, three times daily. Patient in two groups were treated for 8 weeks. After treatment, the clinical evaluations were evaluated, and the scores of PANSS, CGI-SI, PSP, SF-36 and TESS, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was 95.00%, which was significantly higher than that in the control group (83.33%, P < 0.05). After treatment, the PANSS and CGI-SI scores in two groups were lower than those before treatment in the group, while the PSP and SF-36 scores were higher than those before treatment in the group (P < 0.05). The PANSS, CGI-SI, PSP and SF-36 scores in the treatment group were significantly better than those in the control group during the same period (P < 0.05). After treatment, the TESS score in the treatment group was significantly lower than that in the control group (P < 0.05), the incidence of akathisia, insomnia, and constipation in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Treatment of schizophrenia with Niuhuang Ninggong Tablets combined with blonanserin can achieve satisfactory curative effects, which can not only alleviate the patient′s mental symptoms and severity of the condition, but also improve social function and quality of life, and the side effects are milder.

R971

河北省医学科学研究课题计划（20211463）