目的 研究银杏叶提取物注射液联合甲钴胺片和高压氧治疗突发性耳聋的临床疗效。方法 选取2022年1月—2024年8月在天津市泰达医院高压氧科接受治疗的突发性耳聋患者74例作为研究对象，根据干预方案不同将患者分为对照组和治疗组，每组各37例。对照组口服甲钴胺片0.5 mg/次，3次/d，另予以高压氧治疗，1次/d。治疗组在对照组基础上静滴银杏叶提取物注射液，将87.5 mg药物混合250 mL生理盐水，1次/d。两组患者共连续治疗10 d。对比两组临床疗效、症状消失时间、听力阈值、耳鸣程度、血液流变学指标、血清炎症因子指标。结果 治疗组的总有效率是97.30%，高于对照组的总有效率78.38%，组间比较有统计学意义（P＜0.05）。治疗组患者的耳鸣消失时间、耳闷消失时间、眩晕消失时间均短于对照组（P＜0.05）。治疗后两组的250、1 000、4 000 Hz听力阈值、耳鸣残疾评估量表（THI）评分、红细胞压积（HCT）、红细胞沉降率（ESR）、血清淀粉样蛋白A（SAA）、C反应蛋白（CRP）、白细胞介素-6（IL-6）水平均明显降低（P＜0.05），而治疗组的250、1 000、4 000 Hz听力阈值，THI评分，HCT、ESR，血清SAA、CRP、IL-6水平低于对照组（P＜0.05）。结论 银杏叶提取物注射液联合甲钴胺片和高压氧治疗突发性耳聋具有较好的临床疗效，可改善临床症状和血液流变学，降低血清炎症因子水平。

Objective To study the clinical efficacy of Extract of Ginkgo Biloba Leaves Injection combined with Methylcobalamin Tablets and hyperbaric oxygen therapy in treatment of sudden deafness. Methods A total of 74 patients with sudden deafness who received treatment in the Department of Hyperbaric Oxygen of Tianjin Teda Hospital from January 2022 to August 2024 were selected as the research subjects. According to different intervention plans, the patients were divided into control group and treatment group, with 37 patients in each group. The control group was po administered with Methylcobalamin Tablets 0.5 mg/time, 3 times daily, and was also treated with hyperbaric oxygen therapy, once daily. The treatment group were iv administered with Extract of Ginkgo Biloba Leaves Injection on the basis of the control group, and 87.5 mg drug was mixed with 250 mL physiological saline, once daily. Two groups of patients were treated continuously for 10 d. The clinical efficacy, symptom disappearance time, hearing threshold, tinnitus degree, hemorheological indicators, and serum inflammatory factor indicators were compared between two groups. Results The total effective rate of the treatment group was 97.30%, which was higher than the total effective rate of 78.38% in the control group, and the difference was statistically significant between two groups (P < 0.05). The disappearance times of tinnitus, ear tightness, and dizziness in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the hearing thresholds of 250, 1 000, and 4 000 Hz, THI scores, hematocrit (HCT), erythrocyte sedimentation rate (ESR), serum levels of amyloid A (SAA), C-reactive protein (CRP), and interleukin-6 (IL-6) in two groups were significantly reduced (P < 0.05), and the hearing thresholds of 250, 1 000, and 4 000 Hz, THI scores, HCT, ESR, serum levels of SAA, CRP, and IL-6 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Extract of Ginkgo Biloba Leaves Injection combined with Methylcobalamin Tablets and hyperbaric oxygen therapy has good clinical efficacy in treatment of sudden deafness, which can improve clinical symptoms and hemorheology, and reduce serum levels of inflammatory factors.

R971;R987